Literature DB >> 26141928

Autophagy in renal diseases.

Stéphanie De Rechter1,2, Jean-Paul Decuypere3,4, Ekaterina Ivanova5, Lambertus P van den Heuvel5,6, Humbert De Smedt7, Elena Levtchenko8,5, Djalila Mekahli8,5.   

Abstract

Autophagy is the cell biology process in which cytoplasmic components are degraded in lysosomes to maintain cellular homeostasis and energy production. In the healthy kidney, autophagy plays an important role in the homeostasis and viability of renal cells such as podocytes and tubular epithelial cells and of immune cells. Recently, evidence is mounting that (dys)regulation of autophagy is implicated in the pathogenesis of various renal diseases, and might be an attractive target for new renoprotective therapies. In this review, we provide an overview of the role of autophagy in kidney physiology and kidney diseases.

Entities:  

Keywords:  Apoptosis; Autophagy; Cystinosis; Diabetic nephropathy; Fibrosis; Glomerulosclerosis; Ischemia reperfusion injury; Polycystic kidney disease

Mesh：

Substances：

Year:  2015        PMID： 26141928     DOI： 10.1007/s00467-015-3134-2

Source DB:  PubMed          Journal:  Pediatr Nephrol        ISSN： 0931-041X            Impact factor:   3.714


  86 in total

Review 1.  Emerging roles of autophagy in the stressed kidney allograft.

Authors:  Nicolas Pallet
Journal:  Semin Nephrol       Date:  2013-11-22       Impact factor: 5.299

Review 2.  Autophagy in glomerular health and disease.

Authors:  Björn Hartleben; Nicola Wanner; Tobias B Huber
Journal:  Semin Nephrol       Date:  2013-11-22       Impact factor: 5.299

Review 3.  mTOR signaling in autophagy regulation in the kidney.

Authors:  Ken Inoki
Journal:  Semin Nephrol       Date:  2013-11-21       Impact factor: 5.299

Review 4.  Autophagy and aging.

Authors:  David C Rubinsztein; Guillermo Mariño; Guido Kroemer
Journal:  Cell       Date:  2011-09-02       Impact factor: 41.582

Review 5.  mTOR controls kidney epithelia in health and disease.

Authors:  Florian Grahammer; Nicola Wanner; Tobias B Huber
Journal:  Nephrol Dial Transplant       Date:  2014-02       Impact factor: 5.992

6.  Inhibition of intracellular clusterin attenuates cell death in nephropathic cystinosis.

Authors:  Poonam Sansanwal; Li Li; Minnie M Sarwal
Journal:  J Am Soc Nephrol       Date:  2014-07-28       Impact factor: 10.121

7.  Impairment of chaperone-mediated autophagy leads to selective lysosomal degradation defects in the lysosomal storage disease cystinosis.

Authors:  Gennaro Napolitano; Jennifer L Johnson; Jing He; Celine J Rocca; Jlenia Monfregola; Kersi Pestonjamasp; Stephanie Cherqui; Sergio D Catz
Journal:  EMBO Mol Med       Date:  2015-02       Impact factor: 12.137

8.  Direct recording and molecular identification of the calcium channel of primary cilia.

Authors:  Paul G DeCaen; Markus Delling; Thuy N Vien; David E Clapham
Journal:  Nature       Date:  2013-12-12       Impact factor: 49.962

9.  Primary cilia are specialized calcium signalling organelles.

Authors:  Markus Delling; Paul G DeCaen; Julia F Doerner; Sebastien Febvay; David E Clapham
Journal:  Nature       Date:  2013-12-12       Impact factor: 49.962

10.  Ischemic conditioning by short periods of reperfusion attenuates renal ischemia/reperfusion induced apoptosis and autophagy in the rat.

Authors:  Hsing-Hui Wu; Tzu-Yu Hsiao; Chiang-Ting Chien; Ming-Kuen Lai
Journal:  J Biomed Sci       Date:  2009-02-11       Impact factor: 8.410
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  32 in total

1.  Protein kinase Cα drives fibroblast activation and kidney fibrosis by stimulating autophagic flux.

Authors:  Xian Xue; Jiafa Ren; Xiaoli Sun; Yuan Gui; Ye Feng; Bingyan Shu; Wei Wei; Qingmiao Lu; Yan Liang; Weichun He; Junwei Yang; Chunsun Dai
Journal:  J Biol Chem       Date:  2018-05-23       Impact factor: 5.157

2.  Control of lysosomal TRPML1 channel activity and exosome release by acid ceramidase in mouse podocytes.

Authors:  Guangbi Li; Dandan Huang; Jinni Hong; Owais M Bhat; Xinxu Yuan; Pin-Lan Li
Journal:  Am J Physiol Cell Physiol       Date:  2019-07-03       Impact factor: 4.249

Review 3.  Exosomes: Biomarkers and Therapeutic Targets of Diabetic Vascular Complications.

Authors:  Anqi Chen; Hailing Wang; Ying Su; Chunlin Zhang; Yanmei Qiu; Yifan Zhou; Yan Wan; Bo Hu; Yanan Li
Journal:  Front Endocrinol (Lausanne)       Date:  2021-08-12       Impact factor: 5.555

4.  Angiotensin (1-7) protects against renal ischemia-reperfusion injury via regulating expression of NRF2 and microRNAs in Fisher 344 rats.

Authors:  Asif Zaman; Anees A Banday
Journal:  Am J Physiol Renal Physiol       Date:  2022-05-09

5.  p66Shc regulates podocyte autophagy in high glucose environment through the Notch-PTEN-PI3K/Akt/mTOR pathway.

Authors:  Danna Zheng; Mei Tao; Xudong Liang; Yiwen Li; Juan Jin; Qiang He
Journal:  Histol Histopathol       Date:  2019-10-25       Impact factor: 2.303

6.  Rapamycin-induced autophagy protects proximal tubular renal cells against proteinuric damage through the transcriptional activation of the nerve growth factor receptor NGFR.

Authors:  D Vizza; A Perri; G Toteda; S Lupinacci; I Perrotta; D Lofaro; F Leone; P Gigliotti; A La Russa; R Bonofiglio
Journal:  Autophagy       Date:  2018-05-11       Impact factor: 16.016

7.  Histone Deacetylase Inhibitors Reduce Cysts by Activating Autophagy in Polycystic Kidney Disease.

Authors:  Liping Sun; Chaofeng Hu; Xinzhou Zhang
Journal:  Kidney Dis (Basel)       Date:  2019-05-10

8.  Thioredoxin interacting protein (TXNIP) regulates tubular autophagy and mitophagy in diabetic nephropathy through the mTOR signaling pathway.

Authors:  Chunling Huang; Yuan Zhang; Darren J Kelly; Christina Y R Tan; Anthony Gill; Delfine Cheng; Filip Braet; Jin-Sung Park; Carolyn M Sue; Carol A Pollock; Xin-Ming Chen
Journal:  Sci Rep       Date:  2016-07-06       Impact factor: 4.379

9.  Pediatric Nephrology in Primary Care: The Forest for the Trees.

Authors:  Donald E Greydanus; Vimal Master Sankar Raj; Joav Merrick
Journal:  Front Public Health       Date:  2015-10-06

10.  AdipoRon Attenuates Hypertension-Induced Epithelial-Mesenchymal Transition and Renal Fibrosis via Promoting Epithelial Autophagy.

Authors:  Yan Li; Bei Song; Chengchao Ruan; WenJie Xue; Jianrong Zhao
Journal:  J Cardiovasc Transl Res       Date:  2020-10-06       Impact factor: 4.132
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