Jenna Thomason1, Christopher Rentsch2, Edward A Stenehjem3, Alicia I Hidron4, David Rimland5. 1. University of Washington Internal Medicine Residency Program, Harborview Medical Center, Box 359892, 325 9th Ave, Seattle, WA, 98104, USA. Jennalthomason@gmail.com. 2. Atlanta Veterans' Affairs Medical Center, Emory University School of Medicine, 1670 Clairmont Road (111-RIM), Decatur, GA, 30033, USA. Christopher.Rentsch@va.gov. 3. Intermountain Medical Center, 5121 S. Cottonwood Street, Gardner Women and Newborn Center, LL2, Murray, UT, 84157, USA. e.stenehjem@gmail.com. 4. Universidad Pontificia Bolivariana, Hospital Pablo Tobón Uribe, Emory University School of Medicine, Calle 78B # 69-240, Medellín, Colombia. aliciahidron@gmail.com. 5. Atlanta Veterans' Affairs Medical Center, Emory University School of Medicine, 1670 Clairmont Road (111-RIM), Decatur, GA, 30033, USA. david.rimland@va.gov.
Abstract
PURPOSE: Given that vitamin D (25(OH)D) contributes to immune defense, we sought to determine if deficiency of 25(OH)D was significantly associated with methicillin-resistant Staphylococcus aureus (MRSA) infection. METHODS: All patients with 25(OH)D determinations at the Atlanta VAMC from 2007 to 2010 were included in the analyses. These patients were cross-referenced with a prospectively collected MRSA infection database at the AVAMC (2006-2010). Patients with one or more MRSA infections during the study period were considered MRSA-infected patients. Multivariate logistic regression was used to determine the association between 25(OH)D status [deficient (<20 ng/mL) vs. non-deficient (≥20 ng/mL)] and MRSA infection. RESULTS: A total of 6405 patients with 25(OH)D determinations were included in the analyses, of which 401 (6.3 %) were MRSA-infected patients. Mean (SD) vitamin D levels, in ng/mL, were 21.1 (12.4) and 24.0 (12.6) for MRSA-infected patients and non-MRSA infected patients, respectively (p < 0.0001). The multivariate logistic regression model confirmed associations between MRSA infection and sex, race, BMI, HIV status, and 25(OH)D [odds ratio for 25(OH)D: 1.94; 95 % confidence interval: 1.51-2.49]. CONCLUSION: MRSA-infected patients had significantly lower serum vitamin D levels than non-MRSA infected patients, even when controlling for potential confounding variables.
PURPOSE: Given that vitamin D (25(OH)D) contributes to immune defense, we sought to determine if deficiency of 25(OH)D was significantly associated with methicillin-resistant Staphylococcus aureus (MRSA) infection. METHODS: All patients with 25(OH)D determinations at the Atlanta VAMC from 2007 to 2010 were included in the analyses. These patients were cross-referenced with a prospectively collected MRSA infection database at the AVAMC (2006-2010). Patients with one or more MRSA infections during the study period were considered MRSA-infected patients. Multivariate logistic regression was used to determine the association between 25(OH)D status [deficient (<20 ng/mL) vs. non-deficient (≥20 ng/mL)] and MRSA infection. RESULTS: A total of 6405 patients with 25(OH)D determinations were included in the analyses, of which 401 (6.3 %) were MRSA-infected patients. Mean (SD) vitamin D levels, in ng/mL, were 21.1 (12.4) and 24.0 (12.6) for MRSA-infected patients and non-MRSA infected patients, respectively (p < 0.0001). The multivariate logistic regression model confirmed associations between MRSA infection and sex, race, BMI, HIV status, and 25(OH)D [odds ratio for 25(OH)D: 1.94; 95 % confidence interval: 1.51-2.49]. CONCLUSION: MRSA-infected patients had significantly lower serum vitamin D levels than non-MRSA infected patients, even when controlling for potential confounding variables.
Entities:
Keywords:
MRSA infection; Staphyloccoccus aureus; Veteran population; Vitamin D deficiency
Authors: Jacqueline M Major; Barry I Graubard; Kevin W Dodd; Allison Iwan; Bruce H Alexander; Martha S Linet; D Michal Freedman Journal: J Clin Endocrinol Metab Date: 2012-11-08 Impact factor: 5.958
Authors: Mark Claassen; Jan Nouwen; Yue Fang; Alewijn Ott; Henri Verbrugh; Albert Hofman; Alex van Belkum; André Uitterlinden Journal: FEMS Immunol Med Microbiol Date: 2005-02-01