Literature DB >> 26141450

Use of Femoral Head and Neck Ostectomy and Physical Therapy to Manage Osteoarthritis in a Rhesus Macaque (Macaca mulatta).

Mayu Uchihashi1, Joseph A Hampel2, Jean A Nemzek3, Phillip A Saccone4, Kathryn A Eaton3, Megan H Nowland3.   

Abstract

Osteoarthritis is associated with pain and immobility in both humans and animals. However, available resources for osteoarthritis management in captive NHP are limited. This case report describes a novel management strategy for a 10-y-old male macaque with unilateral hindlimb lameness, prominent muscle wasting, and severely limited range of motion. Radiographs of the affected limb showed lytic lesions of the femoral head. To relieve pain and improve mobility, femoral head and neck ostectomy (FHO) was performed, and multiple pharmacotherapies were initiated. The macaque also received a unique method of physical therapy that required no sedation, acted as enrichment, and was implemented by using a conventional caging system. The response to therapy was monitored by measuring thigh circumference in the operated and nonoperated limbs, which demonstrated improvement in both legs. The unique physical therapy in conjunction with surgery and pharmacotherapy benefited the macaque with osteoarthritis by reducing discomfort and improving mobility.

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Year:  2015        PMID: 26141450      PMCID: PMC4485634     

Source DB:  PubMed          Journal:  Comp Med        ISSN: 1532-0820            Impact factor:   0.982


  13 in total

Review 1.  Systematic review of efficacy of nutraceuticals to alleviate clinical signs of osteoarthritis.

Authors:  J-M Vandeweerd; C Coisnon; P Clegg; C Cambier; A Pierson; F Hontoir; C Saegerman; P Gustin; S Buczinski
Journal:  J Vet Intern Med       Date:  2012-03-09       Impact factor: 3.333

2.  Rationale and methods for assessment of pain-depressed behavior in preclinical assays of pain and analgesia.

Authors:  S Stevens Negus; Edward J Bilsky; Gail Pereira Do Carmo; Glenn W Stevenson
Journal:  Methods Mol Biol       Date:  2010

Review 3.  Diagnosis and treatment of osteoarthritis.

Authors:  Jessica K Rychel
Journal:  Top Companion Anim Med       Date:  2010-02

4.  Diagnosis and treatment of degenerative joint disease in a captive male chimpanzee (Pan troglodytes).

Authors:  Elaine N Videan; Michael L Lammey; D Rick Lee
Journal:  J Am Assoc Lab Anim Sci       Date:  2011-03       Impact factor: 1.232

5.  Idiopathic chondrolysis condition in two young, wild-caught Cynomolgus monkeys (Macaca fascicularis) reared in captivity.

Authors:  S Rao; M Bryant; R Herbert; N Sullivan; C Murray; J Bacher; N Safdar
Journal:  Vet Pathol       Date:  2009-01-27       Impact factor: 2.221

6.  Aging in the musculoskeletal system of rhesus monkeys: II. Degenerative joint disease.

Authors:  C J DeRousseau
Journal:  Am J Phys Anthropol       Date:  1985-07       Impact factor: 2.868

7.  Excision of femoral head and neck for treatment of coxofemoral degenerative joint disease in a rhesus macaque (Macaca mulatta).

Authors:  Jason P Dufour; Kathrine Phillippi-Falkenstein; Rudolf P Bohm; Ronald S Veazey; Jean Carnal
Journal:  Comp Med       Date:  2012-12       Impact factor: 0.982

8.  Evaluation of the effects of dietary supplementation with fish oil omega-3 fatty acids on weight bearing in dogs with osteoarthritis.

Authors:  James K Roush; Alan R Cross; Walter C Renberg; Chadwick E Dodd; Kristin A Sixby; Dale A Fritsch; Timothy A Allen; Dennis E Jewell; Daniel C Richardson; Phillip S Leventhal; Kevin A Hahn
Journal:  J Am Vet Med Assoc       Date:  2010-01-01       Impact factor: 1.936

9.  Acupuncture as an adjunct therapy for osteoarthritis in chimpanzees (Pan troglodytes).

Authors:  Elizabeth R Magden; Rachel L Haller; Erica J Thiele; Stephanie J Buchl; Susan P Lambeth; Steven J Schapiro
Journal:  J Am Assoc Lab Anim Sci       Date:  2013-07       Impact factor: 1.232

10.  Procedural sedation: A review of sedative agents, monitoring, and management of complications.

Authors:  Joseph D Tobias; Marc Leder
Journal:  Saudi J Anaesth       Date:  2011-10
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