PURPOSE: We aimed to assess the relation between basic clinical parameters and evolution of solitary pure ground-glass nodules (pGGN) in the lungs. METHODS: Baseline and follow-up computed tomography (CT) of patients with solitary pGGN were selected and two radiologists independently reviewed CTs for nodule characterization. CT features of solitary pGGN were manually measured maximum diameter (D1) and its orthogonal diameter (D2), mean diameter (mD), D1 to D2 ratio as surrogate of roundness, and location according to lobar anatomy. Longitudinal changes were assessed and solitary pGGNs were classified as resolved or persisting. Persisting nodules were further classified as stable or grown according to an increase in mD of ≥2 mm or appearance of solid component. Baseline CT features of solitary pGGNs and clinical metrics of patients were compared between resolved and persisting nodules and, thereafter, between stable and grown lesions. RESULTS: A total of 95 subjects with solitary pGGN were included. After a median 16-month follow-up, 20 nodules resolved, while 75 persisted. Among persisting nodules, 18 were grown and 57 were stable. Grown nodules showed larger D1 and mD compared with stable pGGNs (P < 0.001). Subjects with grown nodules were older (P = 0.021). Logistic regression analyses showed higher likelihood of growth for nodules ≥10 mm (odds ratio [OR], 8.355; P = 0.001) and subjects older than 67 years (OR, 3.656; P = 0.034). CONCLUSION: Nodules ≥10 mm in subjects older than 67 years showed higher likelihood of growth. These data could contribute to a more individual approach to the management of solitary pGGN.
PURPOSE: We aimed to assess the relation between basic clinical parameters and evolution of solitary pure ground-glass nodules (pGGN) in the lungs. METHODS: Baseline and follow-up computed tomography (CT) of patients with solitary pGGN were selected and two radiologists independently reviewed CTs for nodule characterization. CT features of solitary pGGN were manually measured maximum diameter (D1) and its orthogonal diameter (D2), mean diameter (mD), D1 to D2 ratio as surrogate of roundness, and location according to lobar anatomy. Longitudinal changes were assessed and solitary pGGNs were classified as resolved or persisting. Persisting nodules were further classified as stable or grown according to an increase in mD of ≥2 mm or appearance of solid component. Baseline CT features of solitary pGGNs and clinical metrics of patients were compared between resolved and persisting nodules and, thereafter, between stable and grown lesions. RESULTS: A total of 95 subjects with solitary pGGN were included. After a median 16-month follow-up, 20 nodules resolved, while 75 persisted. Among persisting nodules, 18 were grown and 57 were stable. Grown nodules showed larger D1 and mD compared with stable pGGNs (P < 0.001). Subjects with grown nodules were older (P = 0.021). Logistic regression analyses showed higher likelihood of growth for nodules ≥10 mm (odds ratio [OR], 8.355; P = 0.001) and subjects older than 67 years (OR, 3.656; P = 0.034). CONCLUSION: Nodules ≥10 mm in subjects older than 67 years showed higher likelihood of growth. These data could contribute to a more individual approach to the management of solitary pGGN.
Authors: John H M Austin; Kavita Garg; Denise Aberle; David Yankelevitz; Keiko Kuriyama; Hyun-Ju Lee; Elisabeth Brambilla; William D Travis Journal: Radiology Date: 2012-10-15 Impact factor: 11.105
Authors: David P Naidich; Alexander A Bankier; Heber MacMahon; Cornelia M Schaefer-Prokop; Massimo Pistolesi; Jin Mo Goo; Paolo Macchiarini; James D Crapo; Christian J Herold; John H Austin; William D Travis Journal: Radiology Date: 2012-10-15 Impact factor: 11.105
Authors: Chang Min Park; Jin Mo Goo; Tae Jung Kim; Hyun Ju Lee; Kyung Won Lee; Chang Hyun Lee; Young Tae Kim; Kwang Gi Kim; Ho Yun Lee; Eun-Ah Park; Jung-Gi Im Journal: Chest Date: 2008-03-13 Impact factor: 9.410
Authors: Onno M Mets; Pim A de Jong; Ernst Th Scholten; Kaman Chung; Bram van Ginneken; Cornelia M Schaefer-Prokop Journal: Eur Radiol Date: 2016-06-02 Impact factor: 5.315