Literature DB >> 26140603

From Dish to Bedside: Lessons Learned While Translating Findings from a Stem Cell Model of Disease to a Clinical Trial.

John McNeish1, Jason P Gardner2, Brian J Wainger3, Clifford J Woolf4, Kevin Eggan5.   

Abstract

While iPSCs have created unprecedented opportunities for drug discovery, there remains uncertainty concerning the path to the clinic for candidate therapeutics discovered with their use. Here we share lessons that we learned, and believe are generalizable to similar efforts, while taking a discovery made using iPSCs into a clinical trial.
Copyright © 2015 Elsevier Inc. All rights reserved.

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Year:  2015        PMID: 26140603     DOI: 10.1016/j.stem.2015.06.013

Source DB:  PubMed          Journal:  Cell Stem Cell        ISSN: 1875-9777            Impact factor:   24.633


  31 in total

Review 1.  Combining Human and Rodent Genetics to Identify New Analgesics.

Authors:  Alban Latremoliere; Michael Costigan
Journal:  Neurosci Bull       Date:  2017-07-01       Impact factor: 5.203

Review 2.  Impact of traumatic brain injury on amyotrophic lateral sclerosis: from bedside to bench.

Authors:  Colin K Franz; Divya Joshi; Elizabeth L Daley; Rogan A Grant; Kyriakos Dalamagkas; Audrey Leung; John D Finan; Evangelos Kiskinis
Journal:  J Neurophysiol       Date:  2019-05-22       Impact factor: 2.714

Review 3.  Induced pluripotent stem cell technology: a decade of progress.

Authors:  Yanhong Shi; Haruhisa Inoue; Joseph C Wu; Shinya Yamanaka
Journal:  Nat Rev Drug Discov       Date:  2016-12-16       Impact factor: 84.694

Review 4.  Modeling rare diseases with induced pluripotent stem cell technology.

Authors:  Ruthellen H Anderson; Kevin R Francis
Journal:  Mol Cell Probes       Date:  2018-01-05       Impact factor: 2.365

5.  A step forward in disease modelling for mitochondrial diseases.

Authors:  Filippo Zambelli; Claudia Spits
Journal:  Stem Cell Investig       Date:  2017-11-14

6.  Induced pluripotent stem cells, past and future.

Authors:  Eirini P Papapetrou
Journal:  Science       Date:  2016-09-02       Impact factor: 47.728

7.  Resilience to Pain: A Peripheral Component Identified Using Induced Pluripotent Stem Cells and Dynamic Clamp.

Authors:  Malgorzata A Mis; Yang Yang; Brian S Tanaka; Carolina Gomis-Perez; Shujun Liu; Fadia Dib-Hajj; Talia Adi; Rolando Garcia-Milian; Betsy R Schulman; Sulayman D Dib-Hajj; Stephen G Waxman
Journal:  J Neurosci       Date:  2018-11-20       Impact factor: 6.167

Review 8.  Drug screening for human genetic diseases using iPSC models.

Authors:  Matthew S Elitt; Lilianne Barbar; Paul J Tesar
Journal:  Hum Mol Genet       Date:  2018-08-01       Impact factor: 6.150

Review 9.  Stem Cells, Genome Editing, and the Path to Translational Medicine.

Authors:  Frank Soldner; Rudolf Jaenisch
Journal:  Cell       Date:  2018-10-18       Impact factor: 41.582

Review 10.  Pluripotent stem cells in disease modelling and drug discovery.

Authors:  Yishai Avior; Ido Sagi; Nissim Benvenisty
Journal:  Nat Rev Mol Cell Biol       Date:  2016-01-28       Impact factor: 94.444

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