Literature DB >> 26139652

Crystals seen on CSF microscopy in a case of suspected subarachnoid haemorrhage.

Daniel Weiand1, Ian Hanning2, Moussa Mouhamadou3, Debbie Wearmouth1.   

Abstract

Although crystals are rarely identified on cerebrospinal fluid (CSF) microscopy, their presence can be of significant diagnostic value. We report a case of oxalate crystals seen on CSF microscopy of a 43-year-old woman. The patient presented with headaches, nausea and vomiting. CT of the head showed a small focus of hyper-density, suspicious of haemorrhage, in the right side of the pontine cistern. CSF cell count was within the normal range. Although no organisms were seen on microscopy, copious oxalate crystals were seen. The same crystals were seen on microscopy of CSF collected in a fluoride oxalate container used for glucose analysis. A follow-up contrast-enhanced CT angiogram did not demonstrate any abnormalities. It transpired that excess CSF had been collected into a fluoride oxalate container. This had subsequently been decanted into a plain container for microbiological analysis. Correct specimen collection should be emphasised when teaching lumbar puncture technique. 2015 BMJ Publishing Group Ltd.

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Year:  2015        PMID: 26139652      PMCID: PMC4493194          DOI: 10.1136/bcr-2015-210478

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  7 in total

1.  Automated flow cytometric analysis of cerebrospinal fluid.

Authors:  J T Van Acker; J R Delanghe; M R Langlois; Y E Taes; M L De Buyzere; A G Verstraete
Journal:  Clin Chem       Date:  2001-03       Impact factor: 8.327

2.  Videos in clinical medicine. Lumbar puncture.

Authors:  Miles S Ellenby; Ken Tegtmeyer; Susanna Lai; Dana A V Braner
Journal:  N Engl J Med       Date:  2006-09-28       Impact factor: 91.245

3.  When a clear crystal makes a case crystal clear.

Authors:  Rudolf Benz; Rudolf Bena; Max Züger; Tamara Pung; Evelyn Gallus; Christian Weisshaupt; Martin Krause
Journal:  Pract Neurol       Date:  2009-12

4.  Ethylene glycol poisoning: toxicokinetic and analytical factors affecting laboratory diagnosis.

Authors:  A F Eder; C M McGrath; Y G Dowdy; J E Tomaszewski; F M Rosenberg; R B Wilson; B A Wolf; L M Shaw
Journal:  Clin Chem       Date:  1998-01       Impact factor: 8.327

5.  Crystal-Formations in the Spinal Fluid and their Diagnostic Significance.

Authors:  K Zeiner-Henriksen
Journal:  J Neurol Psychopathol       Date:  1935-10

6.  A not so crystal-clear case.

Authors:  Verena Gounden; Yashna Rampursat
Journal:  Clin Chem       Date:  2012-08       Impact factor: 8.327

7.  Revised national guidelines for analysis of cerebrospinal fluid for bilirubin in suspected subarachnoid haemorrhage.

Authors:  Anne Cruickshank; Peter Auld; Robert Beetham; Gillian Burrows; William Egner; Ian Holbrook; Geoff Keir; Emma Lewis; Dina Patel; Ian Watson; Peter White
Journal:  Ann Clin Biochem       Date:  2008-05       Impact factor: 2.057

  7 in total

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