BACKGROUND: BRAF mutation frequencies in melanoma subtypes have clinical implications and offer pathogenetic clues. OBJECTIVES: To characterize BRAF mutation status in melanoma of unknown primary (MUP) patients, in histological melanoma subtypes and by localization of primary tumors. METHODS: In 179 patients with stage IV metastatic melanoma, BRAF mutation status, histological subtype and localization of primary (except for 29 MUP patients) were analyzed. RESULTS: BRAF mutations were found in 44.3%, of which 80.5% were BRAF V600E and 19.5% showed non-V600E BRAF mutations. BRAF mutation frequency depended on histological subtype (57.4% superficial spreading melanoma, 54.7% nodular melanoma, 11.1% mucosal melanoma, 28.6% acral lentiginous melanoma) and concerning non-V600E BRAF mutations on localization of primary. In MUP the BRAF mutation pattern resembled superficial spreading and nodular melanomas. CONCLUSION: BRAF mutation frequencies depend on histological subtype and localization of primary melanoma. Non-V600E BRAF mutations mostly occur in patients with primaries on 'head and neck' as well as 'trunk' but not on 'extremities'.
BACKGROUND:BRAF mutation frequencies in melanoma subtypes have clinical implications and offer pathogenetic clues. OBJECTIVES: To characterize BRAF mutation status in melanoma of unknown primary (MUP) patients, in histological melanoma subtypes and by localization of primary tumors. METHODS: In 179 patients with stage IV metastatic melanoma, BRAF mutation status, histological subtype and localization of primary (except for 29 MUP patients) were analyzed. RESULTS:BRAF mutations were found in 44.3%, of which 80.5% were BRAFV600E and 19.5% showed non-V600EBRAF mutations. BRAF mutation frequency depended on histological subtype (57.4% superficial spreading melanoma, 54.7% nodular melanoma, 11.1% mucosal melanoma, 28.6% acral lentiginous melanoma) and concerning non-V600EBRAF mutations on localization of primary. In MUP the BRAF mutation pattern resembled superficial spreading and nodular melanomas. CONCLUSION:BRAF mutation frequencies depend on histological subtype and localization of primary melanoma. Non-V600EBRAF mutations mostly occur in patients with primaries on 'head and neck' as well as 'trunk' but not on 'extremities'.
Authors: Michael Lattanzi; Yesung Lee; Danny Simpson; Una Moran; Farbod Darvishian; Randie H Kim; Eva Hernando; David Polsky; Doug Hanniford; Richard Shapiro; Russell Berman; Anna C Pavlick; Melissa A Wilson; Tomas Kirchhoff; Jeffrey S Weber; Judy Zhong; Iman Osman Journal: J Natl Cancer Inst Date: 2019-02-01 Impact factor: 13.506
Authors: Thomas Eigentler; Zeinab Assi; Jessica C Hassel; Lucie Heinzerling; Hans Starz; Mark Berneburg; Jürgen Bauer; Claus Garbe Journal: Oncotarget Date: 2016-06-14
Authors: Jacqueline A Turner; Judson G T Bemis; Stacey M Bagby; Anna Capasso; Betelehem W Yacob; Tugs-Saikhan Chimed; Robert Van Gulick; Hannah Lee; Richard Tobin; John J Tentler; Todd Pitts; Martin McCarter; William A Robinson; Kasey L Couts Journal: Oncogene Date: 2018-09-25 Impact factor: 8.756