| Literature DB >> 26137002 |
Weijia Fang1, Caiyun Fu2, Xiaogang Chen1, Xiaozhou Mou3, Fanlong Liu1, Jiong Qian1, Peng Zhao1, Yulong Zheng1, Y I Zheng1, Jing Deng1, Pingjiang Ye4, Yifei Wang5, Shusen Zheng1.
Abstract
To analyze the single nucleotide polymorphisms (SNPs) of two subtypes of neurokinin (NK) receptors, NK1R and NK2R (also known as TAC1R and TAC2R), in colorectal cancer (CRC), peripheral blood samples were collected from 199 CRC patients. Direct-sequencing was performed to identify the NK1R rs10198644 and NK2R rs4644560 SNPs. Genotype results were correlated with clinical factors. The allele frequencies of NK1R rs10198644 GC, CC and GG were 52, 17 and 31%, respectively, while that of NK2R rs4644560 GC, CC, and GG were 36, 50 and 14%, respectively. Patients with NK2R rs4644560 GC exhibited more positive lymph nodes than those with CC (mean, 2.2 vs. 1.3; P=0.016). Further analysis highlighted that the number of positive lymph nodes was also increased in the NK2R rs4644560 GC/NK1R rs10198644 GG group compared with the NK2R rs4644560 GG/NK1R rs10198644 GG group (mean, 2.2 vs. 0.9; P=0.04). These data suggested that the NK2R rs4644560 GC polymorphism alone or combination with NK1R rs10198644 GG may be a promising prognostic marker of lymph node metastasis in CRC patients.Entities:
Keywords: colorectal cancer; neurokinin 2 receptor; positive lymph node; single nucleotide polymorphisms
Year: 2015 PMID： 26137002 PMCID： PMC4467290 DOI： 10.3892/ol.2015.3016
Source DB: PubMed Journal: Oncol Lett ISSN： 1792-1074 Impact factor: 2.967