Elske M Brouwer-Brolsma1, Nikita L van der Zwaluw2, Janneke P van Wijngaarden2, Rosalie A Dhonukshe-Rutten2, Paulette H in 't Veld2, Edith J Feskens2, Paul A Smeets3, Roy P Kessels4, Ondine van de Rest2, Lisette C de Groot2. 1. Division of Human Nutrition, Wageningen University, Wageningen, Netherlands; elske.brouwer-brolsma@wur.nl. 2. Division of Human Nutrition, Wageningen University, Wageningen, Netherlands; 3. Division of Human Nutrition, Wageningen University, Wageningen, Netherlands; Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands; 4. Departments of Geriatrics and Medical Psychology, Radboud University Medical Center, Nijmegen, Netherlands; and Donders Institute for Brain, Cognition, and Behavior, Radboud University Nijmegen, Nijmegen, Netherlands.
Abstract
BACKGROUND: Previous studies have shown beneficial associations between 25-hydroxyvitamin D [25(OH)D] status and cognitive performance, but results are inconclusive. Studies on 25(OH)D status and brain volumetric measures may provide more insight in the potential role of vitamin D in cognitive performance. OBJECTIVES: The aims of this study were to cross-sectionally investigate the association between vitamin D status and brain tissue volumes in 217 Dutch community-dwelling older adults aged ≥65 y and to examine whether surrogate markers of glucose homeostasis act as modifiers in these associations. METHODS: Serum 25(OH)D, plasma glucose, and plasma insulin were analyzed, serving as exposure measures. Estimates of total brain volume, gray matter volume, and white matter volume were obtained using MRI, serving as outcome measures. Associations of serum 25(OH)D, plasma glucose, and plasma insulin concentrations with brain tissue volumes were evaluated using multiple linear regression analyses. Potential effect modification by glucose homeostasis in the association between 25(OH)D and brain volumetric measures was examined by stratification and testing for interaction. RESULTS: After full adjustment, higher serum 25(OH)D concentrations and lower plasma glucose concentrations were associated with larger gray matter volume, [β ± SE: 0.20 ± 0.08 mL (P = 0.02) and -3.26 ± 1.59 mL (P = 0.04), respectively]. There were no associations between serum 25(OH)D and plasma insulin concentrations with total brain volume and white matter volume. Furthermore, there was no evidence for a mediation or modification effect of plasma glucose on the associations between serum 25(OH)D and brain tissue volumes. CONCLUSION: Higher serum 25(OH)D and lower plasma glucose are associated with larger gray matter volume, but not white matter or total brain volume, in a population of Dutch adults aged ≥65 y. This trial was registered at clinicaltrials.gov as NCT00696514.
BACKGROUND: Previous studies have shown beneficial associations between 25-hydroxyvitamin D [25(OH)D] status and cognitive performance, but results are inconclusive. Studies on 25(OH)D status and brain volumetric measures may provide more insight in the potential role of vitamin D in cognitive performance. OBJECTIVES: The aims of this study were to cross-sectionally investigate the association between vitamin D status and brain tissue volumes in 217 Dutch community-dwelling older adults aged ≥65 y and to examine whether surrogate markers of glucose homeostasis act as modifiers in these associations. METHODS: Serum 25(OH)D, plasma glucose, and plasma insulin were analyzed, serving as exposure measures. Estimates of total brain volume, gray matter volume, and white matter volume were obtained using MRI, serving as outcome measures. Associations of serum 25(OH)D, plasma glucose, and plasma insulin concentrations with brain tissue volumes were evaluated using multiple linear regression analyses. Potential effect modification by glucose homeostasis in the association between 25(OH)D and brain volumetric measures was examined by stratification and testing for interaction. RESULTS: After full adjustment, higher serum 25(OH)D concentrations and lower plasma glucose concentrations were associated with larger gray matter volume, [β ± SE: 0.20 ± 0.08 mL (P = 0.02) and -3.26 ± 1.59 mL (P = 0.04), respectively]. There were no associations between serum 25(OH)D and plasma insulin concentrations with total brain volume and white matter volume. Furthermore, there was no evidence for a mediation or modification effect of plasma glucose on the associations between serum 25(OH)D and brain tissue volumes. CONCLUSION: Higher serum 25(OH)D and lower plasma glucose are associated with larger gray matter volume, but not white matter or total brain volume, in a population of Dutch adults aged ≥65 y. This trial was registered at clinicaltrials.gov as NCT00696514.
Authors: Thomas J Littlejohns; Katarina Kos; William E Henley; Iain A Lang; Cedric Annweiler; Olivier Beauchet; Paulo H M Chaves; Bryan R Kestenbaum; Lewis H Kuller; Kenneth M Langa; Oscar L Lopez; David J Llewellyn Journal: PLoS One Date: 2016-05-11 Impact factor: 3.240
Authors: Nikita L van der Zwaluw; Elske M Brouwer-Brolsma; Ondine van de Rest; Janneke P van Wijngaarden; Paulette H In 't Veld; Daniella I Kourie; Karin M A Swart; Anke W Enneman; Suzanne C van Dijk; Nathalie van der Velde; Roy P C Kessels; Paul A M Smeets; Frans J Kok; Rosalie A M Dhonukshe-Rutten; Lisette C P G M de Groot Journal: Nutrients Date: 2016-12-24 Impact factor: 5.717
Authors: May A Beydoun; Danielle Shaked; Sharmin Hossain; Hind A Beydoun; Leslie I Katzel; Christos Davatzikos; Rao P Gullapalli; Stephen L Seliger; Guray Erus; Michele K Evans; Alan B Zonderman; Shari R Waldstein Journal: Front Aging Neurosci Date: 2020-05-25 Impact factor: 5.750
Authors: Mariluce Rodrigues Marques Silva; Waleska Maria Almeida Barros; Mayara Luclécia da Silva; José Maurício Lucas da Silva; Ana Patrícia da Silva Souza; Ana Beatriz Januário da Silva; Matheus Santos de Sousa Fernandes; Sandra Lopes de Souza; Viviane de Oliveira Nogueira Souza Journal: Clinics (Sao Paulo) Date: 2021-11-08 Impact factor: 2.365