Literature DB >> 26136555

Physiological role of NBCe2 in the regulation of electrolyte transport in the distal nephron.

Donghai Wen1, Steven C Sansom2.   

Abstract

The electrogenic Na(+)-HCO3 (-) cotransporter 2 (NBCe2) is a newly discovered protein in the distal nephron. Our understanding is minimal regarding its physiological role in renal electrolyte transport. In this mini-review, we summarize the potential function of NBCe2 in the regulation of blood pressure, acid-base, and K(+) and Ca(2+) transport in the distal nephron.
Copyright © 2015 the American Physiological Society.

Entities:  

Keywords:  Ca2+; K+; NBCe2; acid-base; hypertension

Mesh：

Substances：

Year:  2015        PMID： 26136555      PMCID： PMC6189740          DOI： 10.1152/ajprenal.00192.2015

Source DB:  PubMed          Journal:  Am J Physiol Renal Physiol        ISSN： 1522-1466


  21 in total

1.  Functional characterization of NBC4: a new electrogenic sodium-bicarbonate cotransporter.

Authors:  Pejvak Sassani; Alexander Pushkin; Eitan Gross; Alla Gomer; Natalia Abuladze; Ramanath Dukkipati; Gerardo Carpenito; Ira Kurtz
Journal:  Am J Physiol Cell Physiol       Date:  2002-02       Impact factor: 4.249

2.  Acid incubation reverses the polarity of intercalated cell transporters, an effect mediated by hensin.

Authors:  George J Schwartz; Shuichi Tsuruoka; Soundarapandian Vijayakumar; Snezana Petrovic; Ayesa Mian; Qais Al-Awqati
Journal:  J Clin Invest       Date:  2002-01       Impact factor: 14.808

3.  Positional identification of hypertension susceptibility genes on chromosome 2.

Authors:  Ruth Ann Barkley; Aravinda Chakravarti; Richard S Cooper; R Curtis Ellison; Steven C Hunt; Michael A Province; Stephen T Turner; Alan B Weder; Eric Boerwinkle
Journal:  Hypertension       Date:  2004-01-19       Impact factor: 10.190

4.  Expression and localization of rat NBC4c in liver and renal uroepithelium.

Authors:  Natalia Abuladze; Alexander Pushkin; Sergei Tatishchev; Debra Newman; Pakan Sassani; Ira Kurtz
Journal:  Am J Physiol Cell Physiol       Date:  2004-05-19       Impact factor: 4.249

5.  Severe neurologic impairment in mice with targeted disruption of the electrogenic sodium bicarbonate cotransporter NBCe2 (Slc4a5 gene).

Authors:  Liyo Kao; Lisa M Kurtz; Xuesi Shao; Marios C Papadopoulos; Li Liu; Dean Bok; Steven Nusinowitz; Bryan Chen; Salvatore L Stella; Mark Andre; Josh Weinreb; Serena S Luong; Natik Piri; Jacky M K Kwong; Debra Newman; Ira Kurtz
Journal:  J Biol Chem       Date:  2011-06-24       Impact factor: 5.157

6.  Increased Epithelial Sodium Channel Activity Contributes to Hypertension Caused by Na+-HCO3- Cotransporter Electrogenic 2 Deficiency.

Authors:  Donghai Wen; Yang Yuan; Paige C Warner; Bangchen Wang; Ryan J Cornelius; Jun Wang-France; Huaqing Li; Thomas Boettger; Steven C Sansom
Journal:  Hypertension       Date:  2015-05-04       Impact factor: 10.190

7.  Feedback regulation of Na channels in rat CCT. I. Effects of inhibition of Na pump.

Authors:  R B Silver; G Frindt; E E Windhager; L G Palmer
Journal:  Am J Physiol       Date:  1993-03

8.  Pendrin modulates ENaC function by changing luminal HCO3-.

Authors:  Vladimir Pech; Truyen D Pham; Seongun Hong; Alan M Weinstein; Kathryn B Spencer; Billy Jean Duke; Eric Walp; Young Hee Kim; Roy L Sutliff; Hui-Fang Bao; Douglas C Eaton; Susan M Wall
Journal:  J Am Soc Nephrol       Date:  2010-10-21       Impact factor: 10.121

Review 9.  Active Ca(2+) reabsorption in the connecting tubule.

Authors:  Sandor Boros; René J M Bindels; Joost G J Hoenderop
Journal:  Pflugers Arch       Date:  2008-11-07       Impact factor: 3.657

10.  Salt sensitivity of blood pressure is associated with polymorphisms in the sodium-bicarbonate cotransporter.

Authors:  Robert M Carey; Cynthia D Schoeffel; John J Gildea; John E Jones; Helen E McGrath; Lindsay N Gordon; Min Jeong Park; Rafal S Sobota; Patricia C Underwood; Jonathan Williams; Bei Sun; Benjamin Raby; Jessica Lasky-Su; Paul N Hopkins; Gail K Adler; Scott M Williams; Pedro A Jose; Robin A Felder
Journal:  Hypertension       Date:  2012-09-17       Impact factor: 10.190
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  2 in total

Review 1.  Maintaining K+ balance on the low-Na+, high-K+ diet.

Authors:  Ryan J Cornelius; Bangchen Wang; Jun Wang-France; Steven C Sansom
Journal:  Am J Physiol Renal Physiol       Date:  2016-01-06

Review 2.  The Renal Sodium Bicarbonate Cotransporter NBCe2: Is It a Major Contributor to Sodium and pH Homeostasis?

Authors:  Robin A Felder; Pedro A Jose; Peng Xu; John J Gildea
Journal:  Curr Hypertens Rep       Date:  2016-09       Impact factor: 5.369
  2 in total

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