Fatma Alibaz-Oner1, Sibel Z Aydin1, Servet Akar1, Kenan Aksu1, Sevil Kamali1, Eftal Yucel1, Omer Karadag1, Huseyin Ozer1, Sedat Kiraz1, Fatos Onen1, Murat Inanc1, Gokhan Keser1, Nurullah Akkoc1, Haner Direskeneli1. 1. From the Department of Rheumatology Istanbul, School of Medicine, Marmara University; Department of Rheumatology, Koç University; Department of Rheumatology, Faculty of Medicine, Istanbul University, Istanbul; Department of Rheumatology, School of Medicine, Dokuz Eylul University; Department of Rheumatology, School of Medicine, Ege University, İzmir; Department of Rheumatology, School of Medicine, Baskent University; Department of Rheumatology, School of Medicine, Hacettepe University, Ankara, Turkey; Department of Rheumatology, School of Medicine, Cukurova University, Adana, Turkey.F. Alibaz-Oner, MD, Specialist in Rheumatology, Department of Rheumatology, School of Medicine, Marmara University; S.Z. Aydin, MD, Associate Professor of Rheumatology, Department of Rheumatology, Koç University; S. Akar, MD, Professor of Rheumatology, Department of Rheumatology, School of Medicine, Dokuz Eylul University; K. Aksu, MD, Professor of Rheumatology, Department of Rheumatology, School of Medicine, Ege University; S. Kamali, MD, Professor of Rheumatology, Department of Rheumatology, Faculty of Medicine, Istanbul University;E. Yucel, MD, Professor of Rheumatology, Department of Rheumatology, School of Medicine, Baskent University; O. Karadag, MD, Associate Professor of Rheumatology, Department of Rheumatology, School of Medicine, Hacettepe University; H. Ozer, MD, Professor of Rheumatology, Department of Rheumatology, School of Medicine, Cukurova University; S. Kiraz, MD, Professor of Rheumatology, Department of Rheumatology, School of Medicine, Hacettepe University; F. Onen, MD, Professor of Rheumatology, Department of Rheumatology, School of Medicine, Dokuz Eylul University; M. Inanc, MD, Professor of Rheumatology, Department of Rheumatology, Faculty of Medicine, Istanbul University; G. Keser, MD, Professor of Rheumatology, Department of Rheumatology, School of Medicine, Ege University; N. Akkoc, MD, Professor of Rheumatology, Department of Rheumatology, School of Medicine
Abstract
OBJECTIVE: To assess the Indian Takayasu Clinical Activity Score (ITAS2010) in followup of Takayasu arteritis (TA). METHODS: ITAS2010 forms were filled in prospectively (n = 144). Clinical activity was assessed with physician's global assessment (PGA) and criteria defined by Kerr, et al. RESULTS: ITAS2010 was significantly higher in patients with active disease. Total agreement between ITAS2010 and PGA was 66.4%, and between ITAS2010 and Kerr, et al was 82.8%. During followup, 14 of 15 patients showing vascular progression with imaging were categorized as having inactive disease according to ITAS2010. CONCLUSION: ITAS2010 was discriminatory for activity during the followup, but the agreement between PGA and ITAS2010 was moderate. Future work should include the incorporation of advanced vascular imaging and demonstration of ITAS2010 as a scalable measure and not simply a dichotomous measure of activity/flare versus remission.
OBJECTIVE: To assess the Indian Takayasu Clinical Activity Score (ITAS2010) in followup of Takayasu arteritis (TA). METHODS: ITAS2010 forms were filled in prospectively (n = 144). Clinical activity was assessed with physician's global assessment (PGA) and criteria defined by Kerr, et al. RESULTS: ITAS2010 was significantly higher in patients with active disease. Total agreement between ITAS2010 and PGA was 66.4%, and between ITAS2010 and Kerr, et al was 82.8%. During followup, 14 of 15 patients showing vascular progression with imaging were categorized as having inactive disease according to ITAS2010. CONCLUSION: ITAS2010 was discriminatory for activity during the followup, but the agreement between PGA and ITAS2010 was moderate. Future work should include the incorporation of advanced vascular imaging and demonstration of ITAS2010 as a scalable measure and not simply a dichotomous measure of activity/flare versus remission.
Authors: Sibel Z Aydin; Joanna C Robson; Antoine G Sreih; Catherine Hill; Fatma Alibaz-Oner; Sarah Mackie; Susan Beard; Ahmet Gul; Gülen Hatemi; Tanaz A Kermani; Alfred Mahr; Alexa Meara; Nataliya Milman; Beverley Shea; Gunnar Tómasson; Peter Tugwell; Haner Direskeneli; Peter A Merkel Journal: J Rheumatol Date: 2019-03-15 Impact factor: 4.666