Literature DB >> 26136299

Anti-angiogenic and antiproliferative properties of the lichen substances (-)-usnic acid and vulpinic acid.

Ayşe Tansu Koparal.   

Abstract

The anti-proliferative activities of the lichen substances (-)-usnic acid and vulpinic acid on the viability of HepG2 hepatocarcinoma cells, NS20Y neuroblastoma cells and HUVEC endothelial cells were studied by the MTT assay. The anti-angiogenic potential of the substances was determined by the endothelial tube formation assay. Both lichen substances exhibited strong anti-angiogenic activity and were more cytotoxic to the cancer cell lines than to the normal cell line, but vulpinic acid has more potential as an anti-angiogenic substance because of its low cytotoxicity and stronger anti-angiogenic activity on the HUVEC cell line.

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Year:  2015        PMID： 26136299     DOI： 10.1515/znc-2014-4178

Source DB:  PubMed          Journal:  Z Naturforsch C J Biosci        ISSN： 0341-0382


  13 in total

1.  Anti-breast cancer and anti-angiogenic potential of a lichen-derived small-molecule: barbatolic acid.

Authors:  Mehmet Varol
Journal:  Cytotechnology       Date:  2018-08-28       Impact factor: 2.058

2.  The molecular mechanisms of vulpinic acid induced programmed cell death in melanoma.

Authors:  Sevcan Yangın; Demet Cansaran-Duman; Gamze Guney Eskiler; Sümer Aras
Journal:  Mol Biol Rep       Date:  2022-08-12       Impact factor: 2.742

3.  Design, synthesis and antimicrobial activity of usnic acid derivatives.

Authors:  Kartsev Victor; Lichitsky Boris; Geronikaki Athina; Petrou Anthi; Smiljkovic Marija; Kostic Marina; Radanovic Oliver; Soković Marina
Journal:  Medchemcomm       Date:  2018-04-11       Impact factor: 3.597

4.  The metabolite 5-methyl-1,3-benzenediol and its derivative methyl-2,4-dihydroxy-6-methylbenzoate from the lichen Parmotrema tinctorum with potent apoptotic and anti-angiogenesis effects.

Authors:  Ashrini Bhaktavalsala Suresh; Varalakshmi Kilingar Nadumane
Journal:  3 Biotech       Date:  2021-06-18       Impact factor: 2.893

5.  miR-185-5p response to usnic acid suppresses proliferation and regulating apoptosis in breast cancer cell by targeting Bcl2.

Authors:  Elif Değerli; Vildan Torun; Demet Cansaran-Duman
Journal:  Biol Res       Date:  2020-05-04       Impact factor: 5.612

6.  In Vitro Antigenotoxic, Antihelminthic and Antioxidant Potentials Based on the Extracted Metabolites from Lichen, Candelariella vitellina.

Authors:  Islam El-Garawani; Mahmoud Emam; Waill Elkhateeb; Hesham El-Seedi; Shaden Khalifa; Salwa Oshiba; Shaimaa Abou-Ghanima; Ghoson Daba
Journal:  Pharmaceutics       Date:  2020-05-24       Impact factor: 6.321

7.  Vulpinic Acid Controls Stem Cell Fate toward Osteogenesis and Adipogenesis.

Authors:  Sang Ah Yi; Ki Hong Nam; Sil Kim; Hae Min So; Rhim Ryoo; Jeung-Whan Han; Ki Hyun Kim; Jaecheol Lee
Journal:  Genes (Basel)       Date:  2019-12-23       Impact factor: 4.096

8.  Microwave-Assisted Extraction and HPLC-UV-CD Determination of (S)-usnic Acid in Cladonia foliacea.

Authors:  Valeria Cavalloro; Giorgio Marrubini; Rita Stabile; Daniela Rossi; Pasquale Linciano; Gabriele Gheza; Silvia Assini; Emanuela Martino; Simona Collina
Journal:  Molecules       Date:  2021-01-16       Impact factor: 4.411

9.  Usnic acid deteriorates acidogenicity, acidurance and glucose metabolism of Streptococcus mutans through downregulation of two-component signal transduction systems.

Authors:  Arumugam Priya; Chandra Bose Manish Kumar; Alaguvel Valliammai; Anthonymuthu Selvaraj; Shunmugiah Karutha Pandian
Journal:  Sci Rep       Date:  2021-01-14       Impact factor: 4.379

Review 10.  Anticancer Potential of Lichens' Secondary Metabolites.

Authors:  Zuzana Solárová; Alena Liskova; Marek Samec; Peter Kubatka; Dietrich Büsselberg; Peter Solár
Journal:  Biomolecules       Date:  2020-01-05
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