Literature DB >> 26136173

Effects of Dietary Plant-Origin Glucosylceramide on Bowel Inflammation in DSS-Treated Mice.

Katsuhito Arai1, Yu Mizobuchi, Yoshihiko Tokuji, Kazuhiko Aida, Shinji Yamashita, Masao Ohnishi, Mikio Kinoshita.   

Abstract

The effects of dietary plant-origin glucosylceramide (GlcCer) on symptoms similar to those of inflammatory bowel diseasewere investigated in dextran sulfate sodium salt (DSS)-treated mice. Dietary GlcCer suppressed decreases in body weight due to DSS administration. To determine its effects on the colon, we examined its surface under a microscope following toluidine blue staining. Dietary GlcCer decreased DSS-induced chorionic crypt injury and elevated myeloperoxidase levels. Moreover, dietary GlcCer significantly suppressed the production of cytokines by the intestinal mucosa. These results provide evidence for the suppression of DSS-induced inflammation by dietary GlcCer.

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Year:  2015        PMID： 26136173     DOI： 10.5650/jos.ess15005

Source DB:  PubMed          Journal:  J Oleo Sci        ISSN： 1345-8957            Impact factor:   1.601


  8 in total

1.  Sphingoid base in pineapple glucosylceramide suppresses experimental allergy by binding leukocyte mono-immunoglobulin-like receptor 3.

Authors:  Ayumi Takemura; Nobuaki Ohto; Hiroshige Kuwahara; Masashi Mizuno
Journal:  J Sci Food Agric       Date:  2021-11-11       Impact factor: 4.125

Review 2.  Dietary and Endogenous Sphingolipid Metabolism in Chronic Inflammation.

Authors:  Gregory H Norris; Christopher N Blesso
Journal:  Nutrients       Date:  2017-10-28       Impact factor: 5.717

3.  Chemoenzymatically prepared konjac ceramide inhibits NGF-induced neurite outgrowth by a semaphorin 3A-like action.

Authors:  Seigo Usuki; Noriko Tamura; Shota Sakai; Tomohiro Tamura; Katsuyuki Mukai; Yasuyuki Igarashi
Journal:  Biochem Biophys Rep       Date:  2015-11-19

Review 4.  Exosome-Induced Regulation in Inflammatory Bowel Disease.

Authors:  Huiting Zhang; Liang Wang; Changyi Li; Yue Yu; Yanlin Yi; Jingyu Wang; Dapeng Chen
Journal:  Front Immunol       Date:  2019-06-28       Impact factor: 7.561

5.  Nrp1 is Activated by Konjac Ceramide Binding-Induced Structural Rigidification of the a1a2 Domain.

Authors:  Seigo Usuki; Yoshiaki Yasutake; Noriko Tamura; Tomohiro Tamura; Kunikazu Tanji; Takashi Saitoh; Yuta Murai; Daisuke Mikami; Kohei Yuyama; Kenji Monde; Katsuyuki Mukai; Yasuyuki Igarashi
Journal:  Cells       Date:  2020-02-24       Impact factor: 6.600

Review 6.  Fat of the Gut: Epithelial Phospholipids in Inflammatory Bowel Diseases.

Authors:  Lidiya V Boldyreva; Maryana V Morozova; Snezhanna S Saydakova; Elena N Kozhevnikova
Journal:  Int J Mol Sci       Date:  2021-10-28       Impact factor: 5.923

7.  Glucosylceramide production maintains colon integrity in response to Bacteroides fragilis toxin-induced colon epithelial cell signaling.

Authors:  Logan Patterson; Jawara Allen; Isabella Posey; Jeremy Joseph Porter Shaw; Pedro Costa-Pinheiro; Susan J Walker; Alexis Gademsey; Xinqun Wu; Shaoguang Wu; Nicholas C Zachos; Todd E Fox; Cynthia L Sears; Mark Kester
Journal:  FASEB J       Date:  2020-10-13       Impact factor: 5.834

8.  Japanese traditional dietary fungus koji Aspergillus oryzae functions as a prebiotic for Blautia coccoides through glycosylceramide: Japanese dietary fungus koji is a new prebiotic.

Authors:  Hiroshi Hamajima; Haruka Matsunaga; Ayami Fujikawa; Tomoya Sato; Susumu Mitsutake; Teruyoshi Yanagita; Koji Nagao; Jiro Nakayama; Hiroshi Kitagaki
Journal:  Springerplus       Date:  2016-08-11
  8 in total

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