Literature DB >> 2613544

Visualization of the cytoskeleton in Leydig cells in vitro. Effect of luteinizing hormone and cytoskeletal disrupting drugs.

B Bilińska1.   

Abstract

Effect of LH, vinblastine and cytochalasin B on the cytoskeleton of cultured Leydig cells was investigated using monoclonal antibodies and fluorescence microscopy. After LH addition and treatment with cytoskeletal disrupting drugs, three main effects were observed: 1) increase of androgen level secreted by cultured mouse Leydig cells, 2) changes of cell-shape towards regular and rounded, 3) increase of delta 5,3 beta-HSD activity. The results are discussed in respect to possible involvement of cytoskeleton in the regulation of steroidogenesis.

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Year:  1989        PMID： 2613544     DOI： 10.1007/bf00266854

Source DB:  PubMed          Journal:  Histochemistry        ISSN： 0301-5564


  23 in total

1.  The role of microfilaments in the reponse of Leydig cells to luteinizing hormone.

Authors:  P F Hall; C Charponnier; M Nakamura; G Gabbiani
Journal:  J Steroid Biochem       Date:  1979-10       Impact factor: 4.292

2.  The cytoskeleton and rat granulosa cell steroidogenesis: possible involvement of microtubules and microfilaments.

Authors:  J A Carnegie; B K Tsang
Journal:  Biol Reprod       Date:  1988-02       Impact factor: 4.285

3.  Gonadotropin-induced differentiation of granulosa cells is associated with the co-ordinated regulation of cytoskeletal proteins involved in cell-contact formation.

Authors:  A Ben-Ze'ev; F Kohen; A Amsterdam
Journal:  Differentiation       Date:  1987       Impact factor: 3.880

4.  Developmental regulation of calmodulin, actin, and tubulin RNAs during rat testis differentiation.

Authors:  G R Slaughter; D S Needleman; A R Means
Journal:  Biol Reprod       Date:  1987-12       Impact factor: 4.285

5.  Microtubule disruption does not prevent intracellular transport and secretory processes of cultured fibroblasts.

Authors:  I Virtanen; T Vartio
Journal:  Eur J Cell Biol       Date:  1986-12       Impact factor: 4.492

Review 6.  Hormonal regulation of Leydig cell function.

Authors:  K Purvis; V Hansson
Journal:  Mol Cell Endocrinol       Date:  1978-11       Impact factor: 4.102

7.  Radioimmunoassay of plasma testosterone.

Authors:  M L Dufau; K J Catt; T Tsuruhara; D Ryan
Journal:  Clin Chim Acta       Date:  1972-03       Impact factor: 3.786

8.  Cellular distribution of a protein related to neuronal microtubule-associated protein MAP-2 in Leydig cells.

Authors:  E Dráberová; P Dráber; V Viklický
Journal:  Cell Biol Int Rep       Date:  1986-11

Review 9.  Cytoskeleton: definition, structure and gene regulation.

Authors:  K Weber; M Osborn
Journal:  Pathol Res Pract       Date:  1982       Impact factor: 3.250

10.  Cytochemical and electron microscopic demonstration of organelle translocation and the inhibition of such translocation by colchicine during the mitosis of rat hepatocytes.

Authors:  M Mori; M Satoh; A B Novikoff
Journal:  Exp Cell Res       Date:  1982-10       Impact factor: 3.905
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  2 in total

1.  Hyperplasia and hypertrophy of Leydig cells associated with testicular germ cell tumours containing syncytiotrophoblastic giant cells.

Authors:  U U Zimmerli; C E Hedinger
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1991

Review 2.  Morphology and function of human Leydig cells in vitro. Immunocytochemical and radioimmunological analyses.

Authors:  B Bilinska; M Kotula-Balak; J Sadowska
Journal:  Eur J Histochem       Date:  2009-03-31       Impact factor: 3.188
  2 in total

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