| Literature DB >> 2613530 |
K C Rosenspire1, D L Gildersleeve, C C Massin, S G Mislankar, D M Wieland.
Abstract
Studies were performed to determine whether [18F]6-fluorometaraminol (18F-FMR), a new neuronal heart radiopharmaceutical, is metabolized in vivo and if the metabolites are taken up in heart. Rat, dog, baboon and guinea pig were injected with 18F-FMR and tissue samples were analyzed for metabolites by HPLC. Liver contained the most metabolites of the tissues studied with 25-90% of the radioactivity present as metabolites at 1 h in all the species studied. While metabolites of 18F-FMR are found in blood, no significant accumulation of these metabolites is found in heart (less than or equal to 0.3%) 1 h after i.v. administration in any species except rat. These studies suggest that 18F-FMR is a suitable agent for quantitative imaging of the heart by positron emission tomography.Entities:
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Year: 1989 PMID： 2613530 DOI： 10.1016/0883-2897(89)90147-5
Source DB: PubMed Journal: Int J Rad Appl Instrum B ISSN： 0883-2897