| Literature DB >> 2613522 |
P K Garg1, S K Slade, C L Harrison, M R Zalutsky.
Abstract
The effect of para vs meta substitution on the biological behavior of an intact antibody and an F(ab')2 fragment was investigated. Paired-label studies were performed using 81C6 IgG and OC 125 F(ab')2 labeled using the N-succinimidyl esters of both p-[125I]- and m-[131I]iodobenzoate as well as with the potential catabolites, p-[125I]- and m-[131I]iodobenzoic acid. In all 3 studies, up to 55% lower uptake of 131I in thyroid and stomach was observed, suggesting that the m-substituted species were more inert to dehalogenation in vivo.Entities:
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Year: 1989 PMID： 2613522 DOI： 10.1016/0883-2897(89)90136-0
Source DB: PubMed Journal: Int J Rad Appl Instrum B ISSN： 0883-2897