Literature DB >> 26134889

Selective photosensitization through an AND logic response: optimization of the pH and glutathione response of activatable photosensitizers.

Sundus Erbas-Cakmak1, Fatma Pir Cakmak, Seda Demirel Topel, Taha Bilal Uyar, Engin U Akkaya.   

Abstract

A series of pH and GSH responsive photosensitizers were designed and synthesized. pKa values were optimized by adjusting the inductive contribution of substituents to reach a pH range (6.0-7.4) relevant to the tumour microenvironment. pH-Activatable behaviour and redox mediated release of the quencher from the PS by GSH allow the construction of an AND logic operator for selective photodynamic action in aqueous solutions.

Entities:  

Year:  2015        PMID： 26134889     DOI： 10.1039/c5cc01261a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  8 in total

Review 1.  Fluorescent Photoinduced Electron Transfer (PET) Logic Gates for Acidity (pH) and Redox Potential (pE).

Authors:  David C Magri; Alex D Johnson; Jake C Spiteri
Journal:  J Fluoresc       Date:  2016-11-16       Impact factor: 2.217

2.  Single Chemosensor for Double Analytes: Spectrophotometric Sensing of Cu(2+) and Fluorogenic Sensing of Al(3+) Under Aqueous Conditions.

Authors:  Jie Yang; Ze-li Yuan; Guang-qing Yu; Shun-li He; Qing-hong Hu; Qing Wu; Bo Jiang; Gang Wei
Journal:  J Fluoresc       Date:  2015-11-03       Impact factor: 2.217

3.  Molecular demultiplexer as a terminator automaton.

Authors:  Ilke S Turan; Gurcan Gunaydin; Seylan Ayan; Engin U Akkaya
Journal:  Nat Commun       Date:  2018-02-23       Impact factor: 14.919

4.  Locked and Loaded: β-Galactosidase Activated Photodynamic Therapy Agent Enables Selective Imaging and Targeted Treatment of Glioblastoma Multiforme Cancer Cells.

Authors:  Toghrul Almammadov; Zubeyir Elmazoglu; Gizem Atakan; Dilay Kepil; Guzide Aykent; Safacan Kolemen; Gorkem Gunbas
Journal:  ACS Appl Bio Mater       Date:  2022-08-31

Review 5.  Photodynamic Therapy-Current Limitations and Novel Approaches.

Authors:  Gurcan Gunaydin; M Emre Gedik; Seylan Ayan
Journal:  Front Chem       Date:  2021-06-10       Impact factor: 5.221

6.  A therapeutic keypad lock decoded in drug resistant cancer cells.

Authors:  Gulsen Turkoglu; Gozde Kayadibi Koygun; Mediha Nur Zafer Yurt; Seyda Nur Pirencioglu; Sundus Erbas-Cakmak
Journal:  Chem Sci       Date:  2021-06-17       Impact factor: 9.825

Review 7.  An updated overview on the development of new photosensitizers for anticancer photodynamic therapy.

Authors:  Juan Zhang; Chengshi Jiang; João Paulo Figueiró Longo; Ricardo Bentes Azevedo; Hua Zhang; Luis Alexandre Muehlmann
Journal:  Acta Pharm Sin B       Date:  2017-09-22       Impact factor: 11.413

8.  Molecular memory with downstream logic processing exemplified by switchable and self-indicating guest capture and release.

Authors:  Brian Daly; Thomas S Moody; Allen J M Huxley; Chaoyi Yao; Benjamin Schazmann; Andre Alves-Areias; John F Malone; H Q Nimal Gunaratne; Peter Nockemann; A Prasanna de Silva
Journal:  Nat Commun       Date:  2019-01-21       Impact factor: 14.919
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.