Literature DB >> 26134364

Imatinib-induced gastric antral vascular ectasia in three patients with chronic myeloid leukaemia.

Jeremy Ong1, David Yeung2, Robin Filshie3, Timothy P Hughes2,4,5, Harshal Nandurkar3.   

Abstract

Imatinib is generally well tolerated, but gastric antral vascular ectasia (GAVE) remains a rare but significant complication of imatinib therapy. Whilst this complication has been described in other disease settings, only one other case of GAVE has been reported in a chronic myeloid leukaemia (CML) patient receiving imatinib. Herein, we present three CML patients with GAVE complicating imatinib therapy. In all cases, GAVE resolved only with cessation of imatinib. This confirms a causal relationship between GAVE and imatinib. GAVE should be considered as a possible cause of anaemia and upper gastrointestinal bleeding in patients receiving imatinib therapy.

Entities:  

Keywords:  Chronic myeloid leukaemia; Gastric antral vascular ectasia; Imatinib; Tyrosine kinase inhibitor

Mesh：

Substances：

Year:  2015        PMID： 26134364     DOI： 10.1007/s12185-015-1824-y

Source DB:  PubMed          Journal:  Int J Hematol        ISSN： 0925-5710            Impact factor:   2.490


  11 in total

Review 1.  Gastric antral vascular ectasia in a patient with GIST after treatment with imatinib: case report and literature review.

Authors:  Ehab Saad Aldin; Fadi Mourad; Arafat Tfayli
Journal:  Jpn J Clin Oncol       Date:  2012-03-15       Impact factor: 3.019

2.  A one-year, phase I/IIa, open-label pilot trial of imatinib mesylate in the treatment of systemic sclerosis-associated active interstitial lung disease.

Authors:  Dinesh Khanna; Rajeev Saggar; Maureen D Mayes; Fereidoun Abtin; Philip J Clements; Paul Maranian; Shervin Assassi; Rajan Saggar; Ram R Singh; Daniel E Furst
Journal:  Arthritis Rheum       Date:  2011-11

3.  Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia.

Authors:  Brian J Druker; François Guilhot; Stephen G O'Brien; Insa Gathmann; Hagop Kantarjian; Norbert Gattermann; Michael W N Deininger; Richard T Silver; John M Goldman; Richard M Stone; Francisco Cervantes; Andreas Hochhaus; Bayard L Powell; Janice L Gabrilove; Philippe Rousselot; Josy Reiffers; Jan J Cornelissen; Timothy Hughes; Hermine Agis; Thomas Fischer; Gregor Verhoef; John Shepherd; Giuseppe Saglio; Alois Gratwohl; Johan L Nielsen; Jerald P Radich; Bengt Simonsson; Kerry Taylor; Michele Baccarani; Charlene So; Laurie Letvak; Richard A Larson
Journal:  N Engl J Med       Date:  2006-12-07       Impact factor: 91.245

4.  Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia.

Authors:  B J Druker; M Talpaz; D J Resta; B Peng; E Buchdunger; J M Ford; N B Lydon; H Kantarjian; R Capdeville; S Ohno-Jones; C L Sawyers
Journal:  N Engl J Med       Date:  2001-04-05       Impact factor: 91.245

5.  Endoscopic treatment outcomes in watermelon stomach patients with and without portal hypertension.

Authors:  G S Dulai; D M Jensen; T O G Kovacs; I M Gralnek; R Jutabha
Journal:  Endoscopy       Date:  2004-01       Impact factor: 10.093

6.  The clinical and endoscopic spectrum of the watermelon stomach.

Authors:  C J Gostout; T R Viggiano; D A Ahlquist; K K Wang; M V Larson; R Balm
Journal:  J Clin Gastroenterol       Date:  1992-10       Impact factor: 3.062

7.  Gastric mucosal vascular ectasias causing bleeding in cirrhosis. A distinct entity associated with hypergastrinemia and low serum levels of pepsinogen I.

Authors:  E Quintero; J M Pique; J A Bombi; J M Bordas; J Sentis; M Elena; J Bosch; J Rodes
Journal:  Gastroenterology       Date:  1987-11       Impact factor: 22.682

8.  The watermelon stomach: long-term outcome in patients treated with Nd:YAG laser therapy.

Authors:  S M Liberski; T J McGarrity; R J Hartle; V Varano; D Reynolds
Journal:  Gastrointest Endosc       Date:  1994 Sep-Oct       Impact factor: 9.427

9.  Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors.

Authors:  George D Demetri; Margaret von Mehren; Charles D Blanke; Annick D Van den Abbeele; Burton Eisenberg; Peter J Roberts; Michael C Heinrich; David A Tuveson; Samuel Singer; Milos Janicek; Jonathan A Fletcher; Stuart G Silverman; Sandra L Silberman; Renaud Capdeville; Beate Kiese; Bin Peng; Sasa Dimitrijevic; Brian J Druker; Christopher Corless; Christopher D M Fletcher; Heikki Joensuu
Journal:  N Engl J Med       Date:  2002-08-15       Impact factor: 91.245

10.  Imatinib-induced gastric antral vascular ectasia in a patient with chronic myeloid leukemia.

Authors:  Nawal F Alshehry; Paul Kortan; Jeffrey H Lipton
Journal:  Clin Case Rep       Date:  2014-03-18
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  2 in total

1.  "Imatinib-induced gastric antral vascular ectasia" in a reporting system of the Japanese Adverse Drug Event Report database.

Authors:  Yasuo Oshima; Koichiro Yuji; Arinobu Tojo
Journal:  Int J Hematol       Date:  2016-03-15       Impact factor: 2.490

Review 2.  Gastric Antral Vascular Ectasia Pathogenesis and the Link to the Metabolic Syndrome.

Authors:  Elliot Smith; Jessica Davis; Stephen Caldwell
Journal:  Curr Gastroenterol Rep       Date:  2018-07-02
  2 in total

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