Jianhong Wang1, Ping Li2, Lingling Sun3, Yongmei Sun2, Shibao Fang2, Xuejun Liu4. 1. Organ Transplantation Center, Affiliated Hospital of Qingdao University Qingdao 266003, China. 2. Department of Ultrasound, Affiliated Hospital of Qingdao University Qingdao 266003, China. 3. Department of Pathology, Affiliated Hospital of Qingdao University Qingdao 266003, China. 4. Department of Radiology, Affiliated Hospital of Qingdao University Qingdao 266003, China.
Abstract
OBJECTIVE: To evaluate the differential diagnostic potential of lesion stiffness assessed by the sonoelastographic strain index ratio (SR) for thyroid nodules coexist with Hashimoto thyroiditis (HT). METHODS: A total of 50 focal thyroid nodules from 36 patients with HT (mean age 38.4 years; range 19-77) scheduled for fine-needle aspiration or thyroid surgery were included. After a routine conventional ultrasound evaluation, real-time ultrasound elastography examinations were performed. Strain and area ratios of each lesion were calculated within the same machine. Histological diagnosis was used as the reference standard. The elastography images were scored according to the Asteria elasticity score. The area under the curve (AUC) and cut-off point were obtained by receiver operating curve (ROC). Sensitivity, specificity and accuracy were compared. RESULTS: A total of 38 nodules were benign and 12 were malignant on pathology. The mean strain ratios of benign and malignant lesions were 2.89 and 7.83 respectively. When a cut-off point of 5.03 was used, SR had a sensitivity of 75.0%, a specificity of 92.1% and an accuracy of 84.0%. The AUC values were 0.836. The diagnostic accuracy of the SR was superior to that of elastographic score. CONCLUSION: Real-time elastography is a promising tool for differential diagnosis of thyroid nodules coexist with HT, and SR measurement could be an effective predictor. The best cut-off point for benign and malignant nodules in patients with HT was 5.03.
OBJECTIVE: To evaluate the differential diagnostic potential of lesion stiffness assessed by the sonoelastographic strain index ratio (SR) for thyroid nodules coexist with Hashimoto thyroiditis (HT). METHODS: A total of 50 focal thyroid nodules from 36 patients with HT (mean age 38.4 years; range 19-77) scheduled for fine-needle aspiration or thyroid surgery were included. After a routine conventional ultrasound evaluation, real-time ultrasound elastography examinations were performed. Strain and area ratios of each lesion were calculated within the same machine. Histological diagnosis was used as the reference standard. The elastography images were scored according to the Asteria elasticity score. The area under the curve (AUC) and cut-off point were obtained by receiver operating curve (ROC). Sensitivity, specificity and accuracy were compared. RESULTS: A total of 38 nodules were benign and 12 were malignant on pathology. The mean strain ratios of benign and malignant lesions were 2.89 and 7.83 respectively. When a cut-off point of 5.03 was used, SR had a sensitivity of 75.0%, a specificity of 92.1% and an accuracy of 84.0%. The AUC values were 0.836. The diagnostic accuracy of the SR was superior to that of elastographic score. CONCLUSION: Real-time elastography is a promising tool for differential diagnosis of thyroid nodules coexist with HT, and SR measurement could be an effective predictor. The best cut-off point for benign and malignant nodules in patients with HT was 5.03.
Authors: Katharina König; Ulrich Scheipers; Andreas Pesavento; Andreas Lorenz; Helmut Ermert; Theodor Senge Journal: J Urol Date: 2005-07 Impact factor: 7.450
Authors: David S Cooper; Gerard M Doherty; Bryan R Haugen; Bryan R Hauger; Richard T Kloos; Stephanie L Lee; Susan J Mandel; Ernest L Mazzaferri; Bryan McIver; Furio Pacini; Martin Schlumberger; Steven I Sherman; David L Steward; R Michael Tuttle Journal: Thyroid Date: 2009-11 Impact factor: 6.568
Authors: Shawn D Larson; Lindsey N Jackson; Taylor S Riall; Tatsuo Uchida; Robert P Thomas; Suimin Qiu; B Mark Evers Journal: J Am Coll Surg Date: 2007-02-23 Impact factor: 6.113
Authors: Jin Young Kwak; Eun-Kyung Kim; Kyung Hee Ko; Woo Ik Yang; Min Jung Kim; Eun Ju Son; Ki Keun Oh; Ki Whang Kim Journal: J Ultrasound Med Date: 2007-12 Impact factor: 2.153
Authors: Dario Tumino; Giorgio Grani; Marta Di Stefano; Maria Di Mauro; Maria Scutari; Teresa Rago; Laura Fugazzola; Maria Grazia Castagna; Fabio Maino Journal: Front Endocrinol (Lausanne) Date: 2020-01-23 Impact factor: 5.555