OBJECTIVE: This study aimed to investigate the correlation of serum uric acid with bone mineral density (BMD) and fragility fracture in primary osteoporosis (PO) patients. METHODS: A retrospective analysis of biochemical parameters including bone turnover markers and bone density was done in patients (n=253) received initial treatment for PO from January 2011 to May 2012 at the Shanghai First People's Hospital. RESULTS: Pearson correlation analysis and multiple regression analysis showed that serum uric acid positively correlated with the lumbar spine BMD (P<0.05); serum uric acid negatively correlated with urine calcium/creatinine ratio, but positively correlated with blood 25-hydroxyvitamin D (25 [OH] D) (P<0.05); the serum uric acid in postmenopausal women with the history of fragility fracture was significantly lower than that in women without the this disease history. CONCLUSION: Serum uric acid may be a protective factor of bone metabolism in primary osteoporosis patients.
OBJECTIVE: This study aimed to investigate the correlation of serum uric acid with bone mineral density (BMD) and fragility fracture in primary osteoporosis (PO) patients. METHODS: A retrospective analysis of biochemical parameters including bone turnover markers and bone density was done in patients (n=253) received initial treatment for PO from January 2011 to May 2012 at the Shanghai First People's Hospital. RESULTS: Pearson correlation analysis and multiple regression analysis showed that serum uric acid positively correlated with the lumbar spine BMD (P<0.05); serum uric acid negatively correlated with urine calcium/creatinine ratio, but positively correlated with blood 25-hydroxyvitamin D (25 [OH] D) (P<0.05); the serum uric acid in postmenopausal women with the history of fragility fracture was significantly lower than that in women without the this disease history. CONCLUSION: Serum uric acid may be a protective factor of bone metabolism in primary osteoporosispatients.
Entities:
Keywords:
Osteoporosis; bone density; fractures; uric acid
Authors: S H Ahn; S H Lee; B-J Kim; K-H Lim; S J Bae; E H Kim; H-K Kim; J W Choe; J-M Koh; G S Kim Journal: Osteoporos Int Date: 2013-05-04 Impact factor: 4.507
Authors: M Pirro; M R Mannarino; V Bianconi; S De Vuono; A Sahebkar; F Bagaglia; L Franceschini; A M Scarponi; E Mannarino; T Merriman Journal: Osteoporos Int Date: 2016-10-10 Impact factor: 4.507