Haixia Liu1, Sixin Zhou2, Lin Ma1, Jun Yang3, Hao Yang4. 1. Department of Radiation Oncology, Chinese PLA General Hospital Beijing, China. 2. Department of General Surgery, Chinese PLA General Hospital Beijing, China. 3. Department of Radiation Oncology, First Affiliated Hospital of Xinxiang Medical University Xinxiang, Henan, China. 4. Department of Radiation Oncology, Inner Mongolia Cancer Hospital Hohhot, Inner Mongolia, China.
Abstract
BACKGROUND: Numerous studies have evaluated the association between NQO1 609C>T polymorphism and gastrointestinal (GI) cancer. However, the results remain inconclusive. To obtain a more precise estimation of the relation, we conducted an analysis of all available case-control studies. METHODS: Eligible studies were identified by searching the databases and finally 19 articles were included in the meta-analysis. Odds ratio (OR) with 95% confidence interval (95% CI) was applied to assess the association between NQO1 609C>T polymorphism and GI cancer risk. Z test was used to evaluate the significance of OR and 95% CI. RESULTS: In the overall analysis, there existed a significant association between NQO1 609C>T polymorphism and GI cancer susceptibility (T vs. C: OR = 1.07, 95% CI = 1.01-1.14). The subgroup analysis based on ethnicity showed that NQO1 609C>T polymorphism was associated with susceptibility to GI cancer in mixed population (TT vs. CC: OR = 2.21, 95% CI = 1.44-3.40; TT vs. CT + CC: OR = 2.26, 95% CI = 1.48-3.44; Allele T vs. Allele C: OR = 1.24, 95% CI = 1.05-1.47). For the subgroup analysis according to source of control, a remark relationship of 609C>T with increased risk of GI cancer was observed in HB population (Allele T vs. Allele C: OR = 1.07, 95% CI = 1.01-1.14). CONCLUSION: Our results demonstrated that NQO1 609C>T polymorphism might be associated with susceptibility to GI cancer.
BACKGROUND: Numerous studies have evaluated the association between NQO1 609C>T polymorphism and gastrointestinal (GI) cancer. However, the results remain inconclusive. To obtain a more precise estimation of the relation, we conducted an analysis of all available case-control studies. METHODS: Eligible studies were identified by searching the databases and finally 19 articles were included in the meta-analysis. Odds ratio (OR) with 95% confidence interval (95% CI) was applied to assess the association between NQO1 609C>T polymorphism and GI cancer risk. Z test was used to evaluate the significance of OR and 95% CI. RESULTS: In the overall analysis, there existed a significant association between NQO1 609C>T polymorphism and GI cancer susceptibility (T vs. C: OR = 1.07, 95% CI = 1.01-1.14). The subgroup analysis based on ethnicity showed that NQO1 609C>T polymorphism was associated with susceptibility to GI cancer in mixed population (TT vs. CC: OR = 2.21, 95% CI = 1.44-3.40; TT vs. CT + CC: OR = 2.26, 95% CI = 1.48-3.44; Allele T vs. Allele C: OR = 1.24, 95% CI = 1.05-1.47). For the subgroup analysis according to source of control, a remark relationship of 609C>T with increased risk of GI cancer was observed in HB population (Allele T vs. Allele C: OR = 1.07, 95% CI = 1.01-1.14). CONCLUSION: Our results demonstrated that NQO1 609C>T polymorphism might be associated with susceptibility to GI cancer.
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