Literature DB >> 26131166

Angiotensin-converting enzyme insertion/deletion polymorphism and gastric cancer: a systematic review and meta-analysis.

Lu Gan1, Xinyang Liu1, Zhenhua Wu1, Mingzu Huang1, Xiaowei Zhang1, Weijian Guo1.   

Abstract

Previous case-control studies on the association of the angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism with gastric cancer were controversial. A meta-analysis was conducted to further evaluate the association between polymorphism in the ACE gene I/D and gastric cancer. We searched MEDLINE (PubMed), EMBASE, Web of Science, and CBM without language restrictions to Nov 20, 2014. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association. Eight studies involving 1480 gastric cancer cases and 3773 cancer-free controls were included. Overall, no significant association between ACE I/D polymorphism and gastric cancer risk was observed (OR = 1.15; 95% CI 0.90-1.46, P = 0.26). The subgroup analysis on the basis of H. Pylori status showed the decreased gastric cancer risk in H. Pylori negative subgroup (OR = 0.40; 95% CI: 0.27-0.59; P < 0.00001) rather than in H. Pylori positive subgroup (OR = 1.82, 95% CI: 0.87-3.82, P = 0.11). Subgroup analysis was performed according to ethnicity (Caucasian and Asian). The results showed no genetic effects between ACE I/D polymorphism and gastric cancer risk. This meta-analysis suggested that the ACE gene I/D polymorphism was associated gastric cancer risk in H. Pylori negative subjects.

Entities:  

Keywords:  ACE; Gastric cancer; gene polymorphism; meta-analysis

Year:  2015        PMID： 26131166      PMCID： PMC4483819     

Source DB:  PubMed          Journal:  Int J Clin Exp Med        ISSN： 1940-5901


  16 in total

1.  The number of lymph node metastases in gastric cancer correlates with the angiotensin I-converting enzyme gene insertion/deletion polymorphism.

Authors:  Christoph Röcken; Uwe Lendeckel; Jutta Dierkes; Sabine Westphal; Stacy Carl-McGrath; Brigitte Peters; Sabine Krüger; Peter Malfertheiner; Albert Roessner; Matthias P A Ebert
Journal:  Clin Cancer Res       Date:  2005-04-01       Impact factor: 12.531

Review 2.  New aspects on angiotensin-converting enzyme: from gene to disease.

Authors:  Bruno Baudin
Journal:  Clin Chem Lab Med       Date:  2002-03       Impact factor: 3.694

3.  Influences of chymase and angiotensin I-converting enzyme gene polymorphisms on gastric cancer risks in Japan.

Authors:  Mitsushige Sugimoto; Takahisa Furuta; Naohito Shirai; Mutsuhiro Ikuma; Haruhiko Sugimura; Akira Hishida
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2006-10       Impact factor: 4.254

4.  Implications of the angiotensin converting enzyme gene insertion/deletion polymorphism in health and disease: a snapshot review.

Authors:  Paul R Gard
Journal:  Int J Mol Epidemiol Genet       Date:  2010-03-20

5.  Familial resemblance of plasma angiotensin-converting enzyme level: the Nancy Study.

Authors:  F Cambien; F Alhenc-Gelas; B Herbeth; J L Andre; R Rakotovao; M F Gonzales; J Allegrini; C Bloch
Journal:  Am J Hum Genet       Date:  1988-11       Impact factor: 11.025

6.  Analysis and estimates of the attributable risk for environmental and genetic risk factors in gastric cancer in a Chinese population.

Authors:  Xiaobing Shen; Jiao Zhang; Yingying Yan; Yufeng Yang; Gang Fu; Yuepu Pu
Journal:  J Toxicol Environ Health A       Date:  2009

7.  Is there a link between environmental factors and a genetic predisposition to cancer? A lesson from a familial cluster of gastric cancers.

Authors:  A Rocco; S Staibano; L Ottini; E Mezza; P Somma; R Mariani-Costantini; G Budillon; G Nardone
Journal:  Eur J Cancer       Date:  2003-07       Impact factor: 9.162

8.  Sporadic gastric cancer; a complex interaction of genetic and environmental risk factors.

Authors:  Kenneth E L McColl; Hirotsugu Watabe; Mohammad H Derakhshan
Journal:  Am J Gastroenterol       Date:  2007-09       Impact factor: 10.864

9.  Lack of association between gene polymorphisms of Angiotensin converting enzyme, Nod-like receptor 1, Toll-like receptor 4, FAS/FASL and the presence of Helicobacter pylori-induced premalignant gastric lesions and gastric cancer in Caucasians.

Authors:  Juozas Kupcinskas; Thomas Wex; Jan Bornschein; Michael Selgrad; Marcis Leja; Elona Juozaityte; Gediminas Kiudelis; Laimas Jonaitis; Peter Malfertheiner
Journal:  BMC Med Genet       Date:  2011-08-24       Impact factor: 2.103

10.  No association between angiotensin I converting enzyme (ACE) I/D polymorphism and gastric cancer risk among Japanese.

Authors:  Satoshi Hibi; Yasuyuki Goto; Takafumi Ando; Keitaro Matsuo; Kenji Wakai; Kazuo Tajima; Hidemi Goto; Nobuyuki Hamajima
Journal:  Nagoya J Med Sci       Date:  2011-08       Impact factor: 1.131
View more
  2 in total

1.  Angiotensin-Converting Enzyme Gene Deletion Polymorphism is Associated with Lymph Node Metastasis in Colorectal Cancer Patients in a Chinese Population.

Authors:  Xiao Zheng; Guoli Liu; Gang Cui; Ming Cheng; Nan Zhang; Sanyuan Hu
Journal:  Med Sci Monit       Date:  2017-10-15

2.  Association of ACE I/D and AGTR1 A1166C Gene Polymorphisms and Risk of Uterine Leiomyoma: A Case-Control Study.

Authors:  Farshid Keshavarzi; Batool Teimoori; Farahnaz Farzaneh; Mojgan Mokhtari; Darya Najafi; Saeedeh Salimi
Journal:  Asian Pac J Cancer Prev       Date:  2019-09-01
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.