Association of matrix metalloproteinase-1 -519A/G polymorphism with acute coronary syndrome: a meta-analysis.

Matrix metalloproteinase-1 (MMP-1) has been demonstrated to play an important role in the development and progression of acute coronary syndrome (ACS). Recent studies have shown that MMP-1 -519A/G (rs1144393) polymorphism is associated with the susceptibility to ACS. However, published studies showed inconsistent results. Therefore, a meta-analysis of eligible studies reporting the association between -519A/G polymorphism and ACS was carried out. A systematic search was conducted using PubMed, Web of Science, Cochrane Library, Chinese National Knowledge Infrastructure and Chinese Wan Fang database. Six eligible studies involving 5670 subjects (2868 ACS patients and 2802 healthy controls) were included in this meta-analysis. Overall, this meta-analysis showed a significant association between the rs1144393 polymorphism and ACS (A vs. G: OR = 1.385, 95% CI = 1.019-1.882, P = 0.037; AA vs. AG/GG: OR = 1.547, 95% CI = 1.002-2.389, P = 0.049). Furthermore, subgroup analyses also displayed significant associations between MMP-1 rs1144393 polymorphism and susceptibility to acute myocardial infarction (AA/AG vs. GG: OR = 1.275, 95% CI = 1.016-1.600, P = 0.036) or unstable angina pectoris subjects (A vs. G: OR = 2.128, 95% CI = 1.696-2.670, P < 0.001; AA vs. GG: OR = 2.933, 95% CI = 1.339-6.421, P = 0.007; AA vs. AG/GG: OR = 2.477, 95% CI = 1.457-4.211, P = 0.001). But we found no significant association between the -519A/G polymorphism and ACS either in Asian or Caucasian. In conclusion, our meta-analysis suggests that MMP-1 -519A/G polymorphism was associated with the susceptibility to ACS. However, further large scale case-control studies with rigorous design should be conducted to confirm above conclusions in the future.