Literature DB >> 26131053

The NLRP3 inflammasome and stroke.

Yeqing Tong1, Zhi-Hong Ding2, Fa-Xian Zhan3, Li Cai4, Xiaoxv Yin5, Jin-Lian Ling6, Jian-Jun Ye3, Shuang-Yi Hou3, Zuxun Lu5, Zhi-Hong Wang7, Jia-Fa Liu3.   

Abstract

Inflammasome pattern recognition receptors, which belong to the family of multi-meric proteins, play an important role in innate immunity, including NLRPs, NLRC, and NAIP. Among these receptors, NLRP3 (nucleotide-binding domain (NOD)-like receptor protein 3) inflammasome may activate the inflammation and participate in atherosclerosis, pathophysiology of myocardial infarction, resultin ischemia/reperfusion injury and stroke and other cardiovascular diseases. Effective regulation of NLRP3 may help prevent or even treat stroke. In recent years, the role of inflammation in stroke has attracted much attention, and the in-depth study of its mechanism of action is gradually clear. This mini-review focuses on the association of regulatory mechanisms of NLRP3 inflammasome with the development of stroke, which may supply some clues for future therapies and novel drug targets for stroke.

Entities:  

Keywords:  NLRP3; inflammasome; inflammation; stroke

Year:  2015        PMID： 26131053      PMCID： PMC4483817     

Source DB:  PubMed          Journal:  Int J Clin Exp Med        ISSN： 1940-5901


  68 in total

1.  Factors Associated with Increased Rates of Post-procedural Stroke or Death following Carotid Artery Stent Placement: A Systematic Review.

Authors:  Muhib Khan; Adnan I Qureshi
Journal:  J Vasc Interv Neurol       Date:  2014-05

2.  Nickel induces interleukin-1β secretion via the NLRP3-ASC-caspase-1 pathway.

Authors:  Xiujin Li; Fei Zhong
Journal:  Inflammation       Date:  2014-04       Impact factor: 4.092

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Authors:  Xavier Carné
Journal:  Med Clin (Barc)       Date:  2011-01       Impact factor: 1.725

Review 4.  Immunogenetic susceptibility of atherosclerotic stroke: implications on current and future treatment of vascular inflammation.

Authors:  Thomas J DeGraba
Journal:  Stroke       Date:  2004-10-07       Impact factor: 7.914

5.  Overexpression of IL-18 decreases intimal collagen content and promotes a vulnerable plaque phenotype in apolipoprotein-E-deficient mice.

Authors:  R de Nooijer; J H von der Thüsen; C J N Verkleij; J Kuiper; J W Jukema; E E van der Wall; J C van Berkel; E A L Biessen
Journal:  Arterioscler Thromb Vasc Biol       Date:  2004-10-07       Impact factor: 8.311

Review 6.  Inflammation as a therapeutic target in acute ischemic stroke treatment.

Authors:  Antonino Tuttolomondo; Riccardo Di Sciacca; Domenico Di Raimondo; Chiara Renda; Antonio Pinto; Giuseppe Licata
Journal:  Curr Top Med Chem       Date:  2009       Impact factor: 3.295

Review 7.  Atherosclerosis: basic mechanisms. Oxidation, inflammation, and genetics.

Authors:  J A Berliner; M Navab; A M Fogelman; J S Frank; L L Demer; P A Edwards; A D Watson; A J Lusis
Journal:  Circulation       Date:  1995-05-01       Impact factor: 29.690

Review 8.  Genetic risk factors for stroke and carotid atherosclerosis: insights into pathophysiology from candidate gene approaches.

Authors:  Steve E Humphries; Laleh Morgan
Journal:  Lancet Neurol       Date:  2004-04       Impact factor: 44.182

9.  Activated platelets mediate inflammatory signaling by regulated interleukin 1beta synthesis.

Authors:  S Lindemann; N D Tolley; D A Dixon; T M McIntyre; S M Prescott; G A Zimmerman; A S Weyrich
Journal:  J Cell Biol       Date:  2001-08-06       Impact factor: 10.539

10.  Intravenous immunoglobulin suppresses NLRP1 and NLRP3 inflammasome-mediated neuronal death in ischemic stroke.

Authors:  D Yang-Wei Fann; S Y Lee; S Manzanero; S C Tang; M Gelderblom; P Chunduri; C Bernreuther; M Glatzel; Y L Cheng; J Thundyil; A Widiapradja; K Z Lok; S L Foo; Y C Wang; Y I Li; G R Drummond; M Basta; T Magnus; D G Jo; M P Mattson; C G Sobey; T V Arumugam
Journal:  Cell Death Dis       Date:  2013-09-05       Impact factor: 8.469
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  15 in total

1.  A Polymorphism Within the 3'UTR of NLRP3 is Associated with Susceptibility for Ischemic Stroke in Chinese Population.

Authors:  Zhansheng Zhu; Jing Yan; Chunsong Geng; Dagang Wang; Chaoyang Li; Shuai Feng; Huiping Wang
Journal:  Cell Mol Neurobiol       Date:  2015-12-21       Impact factor: 5.046

2.  NLRP3 inflammasome activation contributes to long-term behavioral alterations in mice injected with lipopolysaccharide.

Authors:  Wei Zhu; Feng-Sheng Cao; Jun Feng; Hua-Weng Chen; Jie-Ru Wan; Qing Lu; Jian Wang
Journal:  Neuroscience       Date:  2016-12-05       Impact factor: 3.590

3.  NLRP3 Inflammasome Activation in the Brain after Global Cerebral Ischemia and Regulation by 17β-Estradiol.

Authors:  Roshni Thakkar; Ruimin Wang; Gangadhara Sareddy; Jing Wang; Dharma Thiruvaiyaru; Ratna Vadlamudi; Quanguang Zhang; Darrell Brann
Journal:  Oxid Med Cell Longev       Date:  2016-10-23       Impact factor: 6.543

4.  Ruscogenin Attenuates Cerebral Ischemia-Induced Blood-Brain Barrier Dysfunction by Suppressing TXNIP/NLRP3 Inflammasome Activation and the MAPK Pathway.

Authors:  Guosheng Cao; Nan Jiang; Yang Hu; Yuanyuan Zhang; Guangyun Wang; Mingzhu Yin; Xiaonan Ma; Kecheng Zhou; Jin Qi; Boyang Yu; Junping Kou
Journal:  Int J Mol Sci       Date:  2016-08-29       Impact factor: 5.923

Review 5.  Programmed Cell Death after Intracerebral Hemorrhage.

Authors:  Tobias Bobinger; Petra Burkardt; Hagen B Huttner; Anatol Manaenko
Journal:  Curr Neuropharmacol       Date:  2018       Impact factor: 7.363

Review 6.  NLRP3 inflammasome as a potential treatment in ischemic stroke concomitant with diabetes.

Authors:  Pu Hong; Ruo-Nan Gu; Feng-Xian Li; Xiao-Xing Xiong; Wen-Bin Liang; Zhi-Jian You; Hong-Fei Zhang
Journal:  J Neuroinflammation       Date:  2019-06-07       Impact factor: 8.322

7.  Netosis and Inflammasomes in Large Vessel Occlusion Thrombi.

Authors:  Stephanie H Chen; Xavier O Scott; Yoandy Ferrer Marcelo; Vania W Almeida; Patricia L Blackwelder; Dileep R Yavagal; Eric C Peterson; Robert M Starke; W Dalton Dietrich; Robert W Keane; Juan Pablo de Rivero Vaccari
Journal:  Front Pharmacol       Date:  2021-01-22       Impact factor: 5.810

8.  Inhibition of NLRP3 Inflammasome Prevents LPS-Induced Inflammatory Hyperalgesia in Mice: Contribution of NF-κB, Caspase-1/11, ASC, NOX, and NOS Isoforms.

Authors:  Abdurrahman Dolunay; Sefika Pinar Senol; Meryem Temiz-Resitoglu; Demet Sinem Guden; Ayse Nihal Sari; Seyhan Sahan-Firat; Bahar Tunctan
Journal:  Inflammation       Date:  2017-04       Impact factor: 4.092

Review 9.  The Role of NLRP3 Inflammasome in Cerebrovascular Diseases Pathology and Possible Therapeutic Targets.

Authors:  Rongrong Bai; Yue Lang; Jie Shao; Yu Deng; Reyisha Refuhati; Li Cui
Journal:  ASN Neuro       Date:  2021 Jan-Dec       Impact factor: 4.146

10.  NLRP3 Inflammasome Mediates Dormant Neutrophil Recruitment following Sterile Lung Injury and Protects against Subsequent Bacterial Pneumonia in Mice.

Authors:  Xiaoli Tian; He Sun; Amy-Jo Casbon; Edward Lim; Kevin P Francis; Judith Hellman; Arun Prakash
Journal:  Front Immunol       Date:  2017-10-31       Impact factor: 7.561
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