Maura Pedrini1, Cinta Moraleda2, Eusebio Macete3, Kizito Gondo4, Bernard J Brabin5, Clara Menéndez6. 1. Maternal, Child and Reproductive Health, Barcelona Centre for International Health Research (CRESIB, Hospital Clínic-Universitat de Barcelona), Barcelona, Spain. 2. Maternal, Child and Reproductive Health, Barcelona Centre for International Health Research (CRESIB, Hospital Clínic-Universitat de Barcelona), Barcelona, Spain Clinical Department, Manhiça Health Research Centre (CISM), Manhiça, Mozambique cinta.moraleda@cresib.cat. 3. Clinical Department, Manhiça Health Research Centre (CISM), Manhiça, Mozambique National Directorate of Health, Ministry of Health, Maputo, Mozambique. 4. Clinical Department, Manhiça Health Research Centre (CISM), Manhiça, Mozambique. 5. Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, Merseyside Global Child Health Group, Academic Madical Centre, University of Amsterdam, Netherlands. 6. Maternal, Child and Reproductive Health, Barcelona Centre for International Health Research (CRESIB, Hospital Clínic-Universitat de Barcelona), Barcelona, Spain Clinical Department, Manhiça Health Research Centre (CISM), Manhiça, Mozambique.
Abstract
OBJECTIVES: To evaluate the clinical, nutritional and neurodevelopment status of HIV-infected children in a high HIV prevalence area. METHODS: All HIV-infected children under 15 years of age attending an outpatient clinic of Mozambique between April and May 2010 were recruited. Clinical data were collected and physical examination was performed. RESULTS: In all, 140 children were recruited. The median age at HIV diagnosis was 2.1 years. Fifty-one percent of the children were classified in WHO clinical Stages 3 or 4. Median age of antiretroviral treatment commencement was 3.9 years. Overall, 68% were undernourished, mainly stunted. Forty-four percent failed to pass the national psychomotor developmental test. CONCLUSIONS: The pathways for early HIV diagnosis and start of antiretrovirals in children should be improved in Mozambique. Malnutrition, especially stunting, and developmental delay were highly prevalent. Further research focused on early diagnosis of neurocognitive disorders and on the indications of antiretroviral treatment commencement based on chronic malnutrition is required.
OBJECTIVES: To evaluate the clinical, nutritional and neurodevelopment status of HIV-infectedchildren in a high HIV prevalence area. METHODS: All HIV-infectedchildren under 15 years of age attending an outpatient clinic of Mozambique between April and May 2010 were recruited. Clinical data were collected and physical examination was performed. RESULTS: In all, 140 children were recruited. The median age at HIV diagnosis was 2.1 years. Fifty-one percent of the children were classified in WHO clinical Stages 3 or 4. Median age of antiretroviral treatment commencement was 3.9 years. Overall, 68% were undernourished, mainly stunted. Forty-four percent failed to pass the national psychomotor developmental test. CONCLUSIONS: The pathways for early HIV diagnosis and start of antiretrovirals in children should be improved in Mozambique. Malnutrition, especially stunting, and developmental delay were highly prevalent. Further research focused on early diagnosis of neurocognitive disorders and on the indications of antiretroviral treatment commencement based on chronic malnutrition is required.
Authors: Minh Diem Dang; Duc Minh Nguyen; Huu Bich Tran; Viet Hung Pham; Daryl Spak; Linh Chi Pham; Thi Quynh Phan; Thi Thanh Dinh; Thi Kim Anh Le; Van Lam Nguyen; Thanh Hai Le; Son Ngoc Hoang; Vu Phuong Linh Dang Journal: Int J Public Health Date: 2017-02-03 Impact factor: 3.380