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Literature DB >> 26130477

Spag6 Negatively Regulates Neuronal Migration During Mouse Brain Development.

Runchuan Yan¹, Xinde Hu¹, Qi Zhang¹, Lingzhen Song¹, Mengdi Zhang¹, Yamei Zhang¹, Shanting Zhao².

Abstract

Sperm-associated antigen 6 (Spag6) is a Chlamydomonas reinhardtii PF16 homologous gene detected in the human testis and is crucial for sperm motility. Neuronal migration is a dynamic process requiring coordinated cytoskeletal remodeling, and Spag6 is co-localized with microtubules in Chinese hamster ovary cells and COS-1 cells. However, the role of Spag6 in neuronal migration remains unclear. Here, we demonstrated that Spag6 was continuously expressed in the developing cerebral cortex. Using in utero electroporation (IUE), we found that overexpression of Spag6 delayed the rate of neuronal migration, rather than affecting the ultimate fate of cortical neurons. Furthermore, overexpression of Spag6 caused a significant decrease in neurite number and length of cortical neurons. Our results indicated that Spag6 controlled neuronal migration as well as neurite branching and elongation.

Entities: Disease Gene Species

Keywords: In utero electroporation; Neuronal migration; Spag6

Mesh：

Substances：

Year: 2015 PMID： 26130477 DOI： 10.1007/s12031-015-0608-4

Source DB: PubMed Journal: J Mol Neurosci ISSN： 0895-8696 Impact factor: 3.444

27 in total

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8. Antagonistic effects of doublecortin and MARK2/Par-1 in the developing cerebral cortex.

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9. A sperm-associated WD repeat protein orthologous to Chlamydomonas PF20 associates with Spag6, the mammalian orthologue of Chlamydomonas PF16.

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10. Lis1 and doublecortin function with dynein to mediate coupling of the nucleus to the centrosome in neuronal migration.

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Review 2. Soma-to-germline transformation in chromatin-linked neurodevelopmental disorders?

Authors: Katherine M Bonefas; Shigeki Iwase
Journal: FEBS J Date: 2021-10-08 Impact factor: 5.622

3. The function of sperm-associated antigen 6 in neuronal proliferation and differentiation.

Authors: Xinde Hu; Runchuan Yan; Xinran Cheng; Lingzhen Song; Wei Zhang; Kaikai Li; Shanting Zhao
Journal: J Mol Histol Date: 2016-08-26 Impact factor: 2.611

4. Spag6 Mutant Mice Have Defects in Development and Function of Spiral Ganglion Neurons, Apoptosis, and Higher Sensitivity to Paclitaxel.

Authors: Xiaofei Li; Lei Xu; Gaoying Sun; Xianmin Wu; Xiaohui Bai; Jianfeng Li; Jerome F Strauss; Zhibing Zhang; Haibo Wang
Journal: Sci Rep Date: 2017-08-17 Impact factor: 4.379