Literature DB >> 26130248

Whether or not to accept a deceased donor kidney offer for a pediatric patient.

Abanti Chaudhuri1, Gerri James, Paul Grimm.   

Abstract

The expansion of the number of children on the deceased donor renal transplant waitlist has far outstripped the supply of organs in most countries, leading to numerous adjustments to increase supply and to maximize the utility of donor organs. The system for organ allocation varies by country based on local laws, priorities, and resources. Adjustments are made to optimize allocation, enhance post-transplant survival benefit, decrease unequal transplant access, and optimize utilization of donated kidneys. Allocation of deceased donor kidneys is based on several criteria; however, the final decision to accept or reject the offered kidney is made by the potential recipient's transplant team (surgeon/nephrologist). Several considerations including assessment of the donor quality, the human leukocyte antigen (HLA) match between the donor and the recipient, numerous recipient factors, the geographical location of the recipient, and the organ all affect the decision to accept the organ or not for a particular recipient. This decision must be made quickly, often on the spot. Maximizing the benefit from this scarce resource raises difficult ethical issues. The philosophies of equity and utility are often competing. In this manuscript, we highlight a representative case that helps to focus on important issues for the pediatric nephrologist to consider while making the decision to accept a deceased donor kidney offer for a particular pediatric patient.

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Year:  2015        PMID: 26130248     DOI: 10.1007/s00467-015-3139-x

Source DB:  PubMed          Journal:  Pediatr Nephrol        ISSN: 0931-041X            Impact factor:   3.714


  23 in total

1.  Twelve years' experience with national sharing of HLA-matched cadaveric kidneys for transplantation.

Authors:  S K Takemoto; P I Terasaki; D W Gjertson; J M Cecka
Journal:  N Engl J Med       Date:  2000-10-12       Impact factor: 91.245

2.  Diminishing significance of HLA matching in kidney transplantation.

Authors:  Xuanming Su; Stefanos A Zenios; Harini Chakkera; Edgar L Milford; Glenn M Chertow
Journal:  Am J Transplant       Date:  2004-09       Impact factor: 8.086

Review 3.  Understanding crossmatch testing in organ transplantation: A case-based guide for the general nephrologist.

Authors:  William R Mulley; John Kanellis
Journal:  Nephrology (Carlton)       Date:  2011-02       Impact factor: 2.506

4.  OPTN/SRTR 2013 Annual Data Report: kidney.

Authors:  A J Matas; J M Smith; M A Skeans; B Thompson; S K Gustafson; D E Stewart; W S Cherikh; J L Wainright; G Boyle; J J Snyder; A K Israni; B L Kasiske
Journal:  Am J Transplant       Date:  2015-01       Impact factor: 8.086

5.  Survival benefit of primary deceased donor transplantation with high-KDPI kidneys.

Authors:  A B Massie; X Luo; E K H Chow; J L Alejo; N M Desai; D L Segev
Journal:  Am J Transplant       Date:  2014-08-19       Impact factor: 8.086

6.  Complement-fixing donor-specific antibodies identified by a novel C1q assay are associated with allograft loss.

Authors:  Scott M Sutherland; Ge Chen; Flavia A Sequeira; Calvin D Lou; Steven R Alexander; Dolly B Tyan
Journal:  Pediatr Transplant       Date:  2011-11-17

7.  Influence of allograft weight to recipient bodyweight ratio on outcome of cadaveric renal transplantation.

Authors:  Ricardo Codas; Fabrice Danjou; Celine Dagot; Xavier Martin; Emmanuel Morelon; Lionel Badet; William Hanf; Palmina Petruzzo
Journal:  Nephrology (Carlton)       Date:  2014-07       Impact factor: 2.506

8.  Complement-binding anti-HLA antibodies and kidney-allograft survival.

Authors:  Alexandre Loupy; Carmen Lefaucheur; Dewi Vernerey; Christof Prugger; Jean-Paul Duong van Huyen; Nuala Mooney; Caroline Suberbielle; Véronique Frémeaux-Bacchi; Arnaud Méjean; François Desgrandchamps; Dany Anglicheau; Dominique Nochy; Dominique Charron; Jean-Philippe Empana; Michel Delahousse; Christophe Legendre; Denis Glotz; Gary S Hill; Adriana Zeevi; Xavier Jouven
Journal:  N Engl J Med       Date:  2013-09-26       Impact factor: 91.245

9.  En bloc kidneys transplanted from infant donors less than 5 kg into pediatric recipients.

Authors:  Wen-Yu Zhao; Lei Zhang; You-Hua Zhu; Yu Chen; Fan-Yuan Zhu; Qian Shen; Hong Xu; Li Zeng
Journal:  Transplantation       Date:  2014-03-15       Impact factor: 4.939

10.  Outcomes of kidneys from donors after cardiac death: implications for allocation and preservation.

Authors:  J E Locke; D L Segev; D S Warren; F Dominici; C E Simpkins; R A Montgomery
Journal:  Am J Transplant       Date:  2007-05-25       Impact factor: 8.086

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  2 in total

1.  Temporal Changes in the Impact of HLA Mismatching Among Pediatric Kidney Transplant Recipients.

Authors:  Jessica M Ruck; Annette M Jackson; Allan B Massie; Dorry L Segev; Niraj Desai; Jacqueline Garonzik-Wang
Journal:  Transplantation       Date:  2019-06       Impact factor: 4.939

2.  Renal allograft survival rates in kidneys initially declined for paediatric transplantation.

Authors:  Matko Marlais; Laura Pankhurst; Kate Martin; Lisa Mumford; E Jane Tizard; Stephen D Marks
Journal:  Pediatr Nephrol       Date:  2018-05-28       Impact factor: 3.714

  2 in total

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