Tugba Arslan Gulen1, Rahmet Guner2, Nevreste Celikbilek3, Siran Keske4, Mehmet Tasyaran2. 1. Department of Infectious Diseases and Clinical Microbiology, Nigde State Hospital, Nigde, Turkey. Electronic address: tarslan81@yahoo.com.tr. 2. Department of Infectious Diseases and Clinical Microbiology, Yıldırım Beyazıt University Faculty of Medicine, Ankara, Turkey. 3. Department of Medical Microbiology, Atatürk Training and Research Hospital, Ankara, Turkey. 4. Department of Infectious Diseases and Clinical Microbiology, Giresun University Faculty of Medicine, Giresun, Turkey.
Abstract
BACKGROUND: A. baumannii is an important nosocomial pathogen associated with high mortality, morbidity and medical cost. AIM: The aim of this study was to investigate risk factors for MDR A. baumannii bacteremia and also evaluate cost of hospitalization of these patients. METHODS: Study was conducted in Ankara Atatürk Training and Research Hospital. Patients who were hospitalized in ICU and diagnosed for nosocomial blood stream infection (BSI) between January 2007 and December 2010 were checked retrospectively. Patients with nosocomial BSI caused by multidrug resistant A. baumannii were compared with the patients who had BSI caused by other Gram-negative microorganisms in terms of risk factors, mortality and medical costs. FINDINGS: In multivariate analysis previous use of carbapenem, quinolone and metronidazole, and SAPS II score were found as independent risk factors. In case group; immunosupression, SAPS II score, and hospital stay until infection were independently associated with mortality in multivariate analysis. CONCLUSION: Our results suggest that the occurrence of MDR A.baumannii bacteremia was related with the usage of the wide spectrum antibiotics, and mortality rates were increased in patients that high SAPS II scores, long term hospitalization. Infection control procedures and limited antibiotic usage are very important for prevent nosocomial infections.
BACKGROUND:A. baumannii is an important nosocomial pathogen associated with high mortality, morbidity and medical cost. AIM: The aim of this study was to investigate risk factors for MDR A. baumannii bacteremia and also evaluate cost of hospitalization of these patients. METHODS: Study was conducted in Ankara Atatürk Training and Research Hospital. Patients who were hospitalized in ICU and diagnosed for nosocomial blood stream infection (BSI) between January 2007 and December 2010 were checked retrospectively. Patients with nosocomial BSI caused by multidrug resistant A. baumannii were compared with the patients who had BSI caused by other Gram-negative microorganisms in terms of risk factors, mortality and medical costs. FINDINGS: In multivariate analysis previous use of carbapenem, quinolone and metronidazole, and SAPS II score were found as independent risk factors. In case group; immunosupression, SAPS II score, and hospital stay until infection were independently associated with mortality in multivariate analysis. CONCLUSION: Our results suggest that the occurrence of MDR A.baumannii bacteremia was related with the usage of the wide spectrum antibiotics, and mortality rates were increased in patients that high SAPS II scores, long term hospitalization. Infection control procedures and limited antibiotic usage are very important for prevent nosocomial infections.
Authors: Sarah Ainsworth; Patrick M Ketter; Jieh-Juen Yu; Rose C Grimm; Holly C May; Andrew P Cap; James P Chambers; M Neal Guentzel; Bernard P Arulanandam Journal: Vaccine Date: 2017-05-15 Impact factor: 3.641