Literature DB >> 26126593

Gene delivery polymer structure-function relationships elucidated via principal component analysis.

C J Bishop1, B Abubaker-Sharif, T Guiriba, S Y Tzeng, J J Green.   

Abstract

Principal component analysis was applied to a biomaterial library of poly(beta-amino ester)s, useful for non-viral gene delivery, to elucidate chemical parameters that drive biological function. Correlative relationships and principal components were analyzed between 24 physico-chemical polymer properties and 3 cell-based functional variables in human glioblastoma cells (transfection, uptake, and viability).

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Year:  2015        PMID： 26126593      PMCID： PMC4568840          DOI： 10.1039/c5cc04417k

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  8 in total

1.  Semi-automated synthesis and screening of a large library of degradable cationic polymers for gene delivery.

Authors:  Daniel G Anderson; David M Lynn; Robert Langer
Journal:  Angew Chem Int Ed Engl       Date:  2003-07-14       Impact factor: 15.336

Review 2.  Non-viral vectors for gene-based therapy.

Authors:  Hao Yin; Rosemary L Kanasty; Ahmed A Eltoukhy; Arturo J Vegas; J Robert Dorkin; Daniel G Anderson
Journal:  Nat Rev Genet       Date:  2014-07-15       Impact factor: 53.242

3.  A novel non-invasive method to assess aortic valve opening in HeartMate II left ventricular assist device patients using a modified Karhunen-Loève transformation.

Authors:  Corey J Bishop; Nathan O Mason; Abdallah G Kfoury; Robert Lux; Sandi Stoker; Kenneth Horton; Stephen E Clayson; Brad Rasmusson; Bruce B Reid
Journal:  J Heart Lung Transplant       Date:  2010-01       Impact factor: 10.247

4.  Effects of base polymer hydrophobicity and end-group modification on polymeric gene delivery.

Authors:  Joel C Sunshine; Marib I Akanda; David Li; Kristen L Kozielski; Jordan J Green
Journal:  Biomacromolecules       Date:  2011-09-09       Impact factor: 6.988

5.  Epileptic seizures can be anticipated by non-linear analysis.

Authors:  J Martinerie; C Adam; M Le Van Quyen; M Baulac; S Clemenceau; B Renault; F J Varela
Journal:  Nat Med       Date:  1998-10       Impact factor: 53.440

6.  Poly(β-amino ester) nanoparticle delivery of TP53 has activity against small cell lung cancer in vitro and in vivo.

Authors:  Chandrashekhar D Kamat; Ron B Shmueli; Nick Connis; Charles M Rudin; Jordan J Green; Christine L Hann
Journal:  Mol Cancer Ther       Date:  2013-01-30       Impact factor: 6.261

7.  The effect and role of carbon atoms in poly(β-amino ester)s for DNA binding and gene delivery.

Authors:  Corey J Bishop; Tiia-Maaria Ketola; Stephany Y Tzeng; Joel C Sunshine; Arto Urtti; Helge Lemmetyinen; Elina Vuorimaa-Laukkanen; Marjo Yliperttula; Jordan J Green
Journal:  J Am Chem Soc       Date:  2013-04-29       Impact factor: 15.419

8.  Subtle changes to polymer structure and degradation mechanism enable highly effective nanoparticles for siRNA and DNA delivery to human brain cancer.

Authors:  Stephany Y Tzeng; Jordan J Green
Journal:  Adv Healthc Mater       Date:  2012-09-26       Impact factor: 9.933
  8 in total
  11 in total

1.  Hydrophobic interactions between polymeric carrier and palmitic acid-conjugated siRNA improve PEGylated polyplex stability and enhance in vivo pharmacokinetics and tumor gene silencing.

Authors:  Samantha M Sarett; Thomas A Werfel; Irene Chandra; Meredith A Jackson; Taylor E Kavanaugh; Madison E Hattaway; Todd D Giorgio; Craig L Duvall
Journal:  Biomaterials       Date:  2016-04-21       Impact factor: 12.479

Review 2.  Exploring the role of polymer structure on intracellular nucleic acid delivery via polymeric nanoparticles.

Authors:  Corey J Bishop; Kristen L Kozielski; Jordan J Green
Journal:  J Control Release       Date:  2015-10-01       Impact factor: 9.776

3.  Quantification of cellular and nuclear uptake rates of polymeric gene delivery nanoparticles and DNA plasmids via flow cytometry.

Authors:  Corey J Bishop; Rebecca L Majewski; Toni-Rose M Guiriba; David R Wilson; Nupura S Bhise; Alfredo Quiñones-Hinojosa; Jordan J Green
Journal:  Acta Biomater       Date:  2016-03-24       Impact factor: 8.947

4.  Polymeric nanoparticles as cancer-specific DNA delivery vectors to human hepatocellular carcinoma.

Authors:  Camila G Zamboni; Kristen L Kozielski; Hannah J Vaughan; Maisa M Nakata; Jayoung Kim; Luke J Higgins; Martin G Pomper; Jordan J Green
Journal:  J Control Release       Date:  2017-03-27       Impact factor: 9.776

Review 5.  Gene delivery nanoparticles to modulate angiogenesis.

Authors:  Jayoung Kim; Adam C Mirando; Aleksander S Popel; Jordan J Green
Journal:  Adv Drug Deliv Rev       Date:  2016-11-30       Impact factor: 15.470

Review 6.  Advances in the polymeric delivery of nucleic acid vaccines.

Authors:  Gang Chen; Bowen Zhao; Elena F Ruiz; Fuwu Zhang
Journal:  Theranostics       Date:  2022-05-13       Impact factor: 11.600

Review 7.  Engineering DNA vaccines against infectious diseases.

Authors:  Jihui Lee; Shreedevi Arun Kumar; Yong Yu Jhan; Corey J Bishop
Journal:  Acta Biomater       Date:  2018-08-31       Impact factor: 8.947

Review 8.  Automation and data-driven design of polymer therapeutics.

Authors:  Rahul Upadhya; Shashank Kosuri; Matthew Tamasi; Travis A Meyer; Supriya Atta; Michael A Webb; Adam J Gormley
Journal:  Adv Drug Deliv Rev       Date:  2020-11-24       Impact factor: 15.470

9.  High-throughput evaluation of polymeric nanoparticles for tissue-targeted gene expression using barcoded plasmid DNA.

Authors:  Jayoung Kim; Hannah J Vaughan; Camila G Zamboni; Joel C Sunshine; Jordan J Green
Journal:  J Control Release       Date:  2021-07-20       Impact factor: 11.467

10.  Optimisation and feature selection of poly-beta-amino-ester as a drug delivery system for cartilage.

Authors:  Stefano Perni; Polina Prokopovich
Journal:  J Mater Chem B       Date:  2020-06-17       Impact factor: 6.331
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