Literature DB >> 2612569

Effects of the novel compound, Hoe 065, upon impaired learning and memory in rodents.

F J Hock1, H J Gerhards, G Wiemer, J Stechl, W Rüger, H Urbach.   

Abstract

The effects of Hoe 065 (n-octyl 2-[N-[(S)-1-ethoxycarbonyl-3-phenylpropyl]-L-alanyl]-(1S,3S, 5S)-2-azabicyclo [3.3.0]octane-3-carboxylate maleate salt) were studied on the performance of mice and rats in different learning tasks. Hoe 065 prevented the disruption of memory induced by scopolamine administered before training. The results indicate that Hoe 065 improves cognitive function in different tasks.

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Year:  1989        PMID: 2612569     DOI: 10.1016/0014-2999(89)90431-7

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN: 0014-2999            Impact factor:   4.432


  2 in total

Review 1.  Behavioral screening for cognition enhancers: from indiscriminate to valid testing: Part I.

Authors:  M Sarter; J Hagan; P Dudchenko
Journal:  Psychopharmacology (Berl)       Date:  1992       Impact factor: 4.530

2.  Mnemogenic effects of injecting RA-octil, a CE-inhibitor derivate, systemically or into the basal forebrain.

Authors:  P Gerhardt; R U Hasenöhrl; F J Hock; J P Huston
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

  2 in total

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