BACKGROUND: Voxel-based morphometry has been used to explore gray matter alterations in cocaine and methamphetamine dependence. However, the results of this research are inconsistent. OBJECTIVES: The current study meta-analytically examined neuroimaging findings of all studies published before 2014 using the Anisotropic Effect-Size Signed Differential Mapping (ES-SDM). METHODS: Independent investigators searched four major databases for relevant neuroimaging studies involving cocaine and methamphetamine dependence. Nine cocaine and four methamphetamine studies met inclusion criteria. RESULTS: Results indicated that cocaine- and methamphetamine-dependent patients share overlapping regional gray matter abnormalities compared to healthy controls. However, subgroup analysis showed some regional differences; with methamphetamine showing more prominent reductions in the left superior temporal gyrus and the right inferior parietal lobe. Reductions in the right insula and the left superior frontal gyrus were more prominent in cocaine dependence. Moderator analyses indicated that with longer use, cocaine is associated with reductions in the right hippocampus, right middle temporal gyrus, and right inferior frontal gyrus, while methamphetamine is associated with reductions in the left precentral gyrus and the right supramarginal gyrus. CONCLUSION: These findings indicate that cocaine and methamphetamine dependence are significantly and differentially associated with gray matter abnormalities. Results also point to possible gray matter recovery after abstinence from methamphetamine. Although the sample size was adequate, these findings should be considered preliminary and analyses should be revisited with additional primary research focusing on long or short-term duration of use, as well as the length of abstinence.
BACKGROUND: Voxel-based morphometry has been used to explore gray matter alterations in cocaine and methamphetamine dependence. However, the results of this research are inconsistent. OBJECTIVES: The current study meta-analytically examined neuroimaging findings of all studies published before 2014 using the Anisotropic Effect-Size Signed Differential Mapping (ES-SDM). METHODS: Independent investigators searched four major databases for relevant neuroimaging studies involving cocaine and methamphetamine dependence. Nine cocaine and four methamphetamine studies met inclusion criteria. RESULTS: Results indicated that cocaine- and methamphetamine-dependent patients share overlapping regional gray matter abnormalities compared to healthy controls. However, subgroup analysis showed some regional differences; with methamphetamine showing more prominent reductions in the left superior temporal gyrus and the right inferior parietal lobe. Reductions in the right insula and the left superior frontal gyrus were more prominent in cocaine dependence. Moderator analyses indicated that with longer use, cocaine is associated with reductions in the right hippocampus, right middle temporal gyrus, and right inferior frontal gyrus, while methamphetamine is associated with reductions in the left precentral gyrus and the right supramarginal gyrus. CONCLUSION: These findings indicate that cocaine and methamphetamine dependence are significantly and differentially associated with gray matter abnormalities. Results also point to possible gray matter recovery after abstinence from methamphetamine. Although the sample size was adequate, these findings should be considered preliminary and analyses should be revisited with additional primary research focusing on long or short-term duration of use, as well as the length of abstinence.
Authors: Jonatan Ottino-González; Anne Uhlmann; Sage Hahn; Zhipeng Cao; Renata B Cupertino; Nathan Schwab; Nicholas Allgaier; Nelly Alia-Klein; Hamed Ekhtiari; Jean-Paul Fouche; Rita Z Goldstein; Chiang-Shan R Li; Christine Lochner; Edythe D London; Maartje Luijten; Sadegh Masjoodi; Reza Momenan; Mohammad Ali Oghabian; Annerine Roos; Dan J Stein; Elliot A Stein; Dick J Veltman; Antonio Verdejo-García; Sheng Zhang; Min Zhao; Na Zhong; Neda Jahanshad; Paul M Thompson; Patricia Conrod; Scott Mackey; Hugh Garavan Journal: Drug Alcohol Depend Date: 2021-11-25 Impact factor: 4.492
Authors: Edith V Sullivan; Natalie M Zahr; Stephanie A Sassoon; Wesley K Thompson; Dongjin Kwon; Kilian M Pohl; Adolf Pfefferbaum Journal: JAMA Psychiatry Date: 2018-05-01 Impact factor: 21.596
Authors: Yann Chye; Scott Mackey; Boris A Gutman; Christopher R K Ching; Albert Batalla; Sara Blaine; Samantha Brooks; Elisabeth C Caparelli; Janna Cousijn; Alain Dagher; John J Foxe; Anna E Goudriaan; Robert Hester; Kent Hutchison; Neda Jahanshad; Anne M Kaag; Ozlem Korucuoglu; Chiang-Shan R Li; Edythe D London; Valentina Lorenzetti; Maartje Luijten; Rocio Martin-Santos; Shashwath A Meda; Reza Momenan; Angelica Morales; Catherine Orr; Martin P Paulus; Godfrey Pearlson; Liesbeth Reneman; Lianne Schmaal; Rajita Sinha; Nadia Solowij; Dan J Stein; Elliot A Stein; Deborah Tang; Anne Uhlmann; Ruth van Holst; Dick J Veltman; Antonio Verdejo-Garcia; Reinout W Wiers; Murat Yücel; Paul M Thompson; Patricia Conrod; Hugh Garavan Journal: Addict Biol Date: 2019-11-20 Impact factor: 4.093