Literature DB >> 2612544

Transdermal delivery of nicotine in normal human volunteers: a single dose and multiple dose study.

Y B Bannon1, J Corish, O I Corrigan, J G Devane, M Kavanagh, S Mulligan.   

Abstract

The absorption of nicotine delivered by a transdermal delivery system (TDS) was investigated in two separate studies, (A) a dose proportionality study and (B) a multiple dose study. In the dose range of 15-60 mg nicotine, the AUC and Cmax values were proportional to the dose. The levels achieved were in the same range as reported in smokers, following absorption from nicotine chewing gum. The TDS used in the present study produced sustained levels of nicotine for 24 h. No significant accumulation of nicotine was evident as a result of multiple dose administration using a 30-mg nicotine patch. Absorption of nicotine from the TDS was 80-90% and the rate of delivery was similar during both studies.

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Year:  1989        PMID： 2612544     DOI： 10.1007/bf00679785

Source DB:  PubMed          Journal:  Eur J Clin Pharmacol        ISSN： 0031-6970            Impact factor:   2.953


  13 in total

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Authors:  M A Russell; C Feyerabend
Journal:  Drug Metab Rev       Date:  1978       Impact factor: 4.518

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Journal:  Clin Pharmacol Ther       Date:  1984-12       Impact factor: 6.875

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Authors:  P Jacob; M Wilson; N L Benowitz
Journal:  J Chromatogr       Date:  1981-01-02

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Authors:  M Curvall; E Kazemi-Vala; C R Enzell
Journal:  J Chromatogr       Date:  1982-11-12

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Authors:  J R Hughes; S A Miller
Journal:  JAMA       Date:  1984 Nov 23-30       Impact factor: 56.272

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Authors:  J R Hughes; D K Hatsukami; R W Pickens; D Krahn; S Malin; A Luknic
Journal:  Psychopharmacology (Berl)       Date:  1984       Impact factor: 4.530

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Authors:  J Rosenberg; N L Benowitz; P Jacob; K M Wilson
Journal:  Clin Pharmacol Ther       Date:  1980-10       Impact factor: 6.875

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Authors:  C K Svensson
Journal:  Clin Pharmacokinet       Date:  1987-01       Impact factor: 6.447

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Authors:  M A Russell; M J Jarvis; G Sutherland; C Feyerabend
Journal:  JAMA       Date:  1987-06-19       Impact factor: 56.272

10.  Smokers of low-yield cigarettes do not consume less nicotine.

Authors:  N L Benowitz; S M Hall; R I Herning; P Jacob; R T Jones; A L Osman
Journal:  N Engl J Med       Date:  1983-07-21       Impact factor: 91.245
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  6 in total

1.  Sensitivity and tolerance to nicotine in smokers and nonsmokers.

Authors:  E D Srivastava; M A Russell; C Feyerabend; J G Masterson; J Rhodes
Journal:  Psychopharmacology (Berl)       Date:  1991       Impact factor: 4.530

2.  High dose transdermal nicotine therapy for heavy smokers: safety, tolerability and measurement of nicotine and cotinine levels.

Authors:  P A Fredrickson; R D Hurt; G M Lee; L Wingender; I T Croghan; G Lauger; L Gomez-Dahl; K P Offord
Journal:  Psychopharmacology (Berl)       Date:  1995-12       Impact factor: 4.530

Review 3.  Ulcerative colitis in smokers, non-smokers and ex-smokers.

Authors:  Guillermo Bastida; Belén Beltrán
Journal:  World J Gastroenterol       Date:  2011-06-14       Impact factor: 5.742

4.  In Silico Modelling of Transdermal and Systemic Kinetics of Topically Applied Solutes: Model Development and Initial Validation for Transdermal Nicotine.

Authors:  Tao Chen; Guoping Lian; Panayiotis Kattou
Journal:  Pharm Res       Date:  2016-03-08       Impact factor: 4.200

5.  Long-term nicotine substitution after application of a 16-hour nicotine patch in smoking cessation.

Authors:  J Nørregaard; P Tønnesen; K Simonsen; U Säwe
Journal:  Eur J Clin Pharmacol       Date:  1992       Impact factor: 2.953

6.  Comprehensive Parent-Metabolite PBPK/PD Modeling Insights into Nicotine Replacement Therapy Strategies.

Authors:  Lukas Kovar; Dominik Selzer; Hannah Britz; Neal Benowitz; Gideon St Helen; Yvonne Kohl; Robert Bals; Thorsten Lehr
Journal:  Clin Pharmacokinet       Date:  2020-09       Impact factor: 6.447
  6 in total

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