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Literature DB >> 2612513

Blood concentrations after accidental cyclosporin overdose.

K de Meer¹, R H Houwen, C M Bijleveld, D R Uges, M J Slooff.

Abstract

Two cases of children are reported with an accidental oral overdose of cyclosporin in whom blood concentrations were monitored. Despite a tenfold oral overdose, the peak blood concentrations of cyclosporin in both patients were only moderately increased above therapeutic levels. Apart from a transient rise in blood pressure in one patient, no toxic effects of cyclosporin were noticed.

Entities: Chemical Disease Species

Mesh：

Substances：
Cyclosporins

Year: 1989 PMID： 2612513 DOI： 10.1007/bf01958287

Source DB: PubMed Journal: Eur J Pediatr ISSN： 0340-6199 Impact factor: 3.183

9 in total

1. Cyclosporine Monitoring and Pharmacokinetics in Pediatrie Liver Transplant Patients.

Authors: G Burckart; T Starzl; L Williams; A Sanghvi; C Gartner; R Venkataramanan; B Zitelli; J Malatack; A Urbach; W Diven; R Ptachcinski; B Shaw; S Iwatsuki
Journal: Transplant Proc Date: 1985-02 Impact factor: 1.066

2. An acute overdose of cyclosporine.

Authors: T J Schroeder; N K Wadhwa; A J Pesce; M R First
Journal: Transplantation Date: 1986-03 Impact factor: 4.939

3. Huge cyclosporin overdose with favourable outcome.

Authors: R W Baumhefner; L W Myers; G W Ellison; W W Tourtellote; G W Belendiuk; A Wilkinson; B Levine; G M Danovitch
Journal: Lancet Date: 1987-08-08 Impact factor: 79.321

4. Activated charcoal in acute cyclosporin overdose.

Authors: N Honcharik; S Anthone
Journal: Lancet Date: 1985-05-04 Impact factor: 79.321

5. High-performance liquid chromatographic determination of cyclosporin A in human plasma and urine.

Authors: W Niederberger; P Schaub; T Beveridge
Journal: J Chromatogr Date: 1980-06-13

6. Central nervous system toxicity after liver transplantation. The role of cyclosporine and cholesterol.

Authors: P C de Groen; A J Aksamit; J Rakela; G S Forbes; R A Krom
Journal: N Engl J Med Date: 1987-10-01 Impact factor: 91.245

Review 7. Clinical pharmacokinetics of cyclosporin.

Authors: R J Ptachcinski; R Venkataramanan; G J Burckart
Journal: Clin Pharmacokinet Date: 1986 Mar-Apr Impact factor: 6.447

Review 8. Cyclosporine.

Authors: R J Ptachcinski; G J Burckart; R Venkataramanan
Journal: Drug Intell Clin Pharm Date: 1985-02

9. Accidental massive IV administration of cyclosporine in man.

Authors: P E Wallemacq; M L Lesne
Journal: Drug Intell Clin Pharm Date: 1985-01