Marta Santos1, Carla Correia-Gomes2, Ricardo Marcos1, Andreia Santos3, Augusto De Matos4, Carlos Lopes5, Patrícia Dias-Pereira6. 1. Department of Microscopy, Institute of Biomedical Sciences Abel Salazar, ICBAS-UPorto, University of Porto, Porto, Portugal. 2. Epidemiology Research Unit, Future Farming Systems, Scotland's Rural College, Inverness, U.K. 3. Faculty of Veterinary Medicine, Lusófona University of Humanities and Technologies, Lisbon, Portugal. 4. Department of Veterinary Clinics, Institute of Biomedical Sciences Abel Salazar, ICBAS-UPorto, University of Porto, Porto, Portugal Animal Science and Study Central, Food and Agrarian Sciences and Technologies Institute, University of Porto, Porto, Portugal. 5. Department of Pathology and Molecular Immunology, Institute of Biomedical Sciences Abel Salazar, ICBAS-UPorto, University of Porto, Porto, Portugal. 6. Department of Pathology and Molecular Immunology, Institute of Biomedical Sciences Abel Salazar, ICBAS-UPorto, University of Porto, Porto, Portugal pdiaspereira@yahoo.com.br.
Abstract
BACKGROUND/AIM: In the past decade, the human Nottingham histological grade (NHG) has been applied to canine mammary carcinomas (CMC). The Nottingham Prognostic Index (NPI) enables identification of more aggressive human breast cancer. The prognostic value of grading parameters and NPI has never been detailed in CMC. The aim of the present study was to assess the prognostic value of NHG, its parameters and NPI. MATERIALS AND METHODS: Univariable and multivariable analyses were used to assess the prognostic value of NHG, its parameters and NPI in a cohort of 59 dogs with CMC. RESULTS: Short disease-free interval and overall survival were associated with higher NHG, particularly of grade III. Only high nuclear pleomorphism score was significantly associated with poor survival. NPI exhibited a strong predictive value for disease progression. CONCLUSION: NHG, nuclear pleomorphism and NPI have prognostic value in CMC. Nuclear pleomorphism is an independent prognostic factor. Evaluation of nuclear pleomorphism should be included in routine pathology reports. Copyright
BACKGROUND/AIM: In the past decade, the human Nottingham histological grade (NHG) has been applied to canine mammary carcinomas (CMC). The Nottingham Prognostic Index (NPI) enables identification of more aggressive humanbreast cancer. The prognostic value of grading parameters and NPI has never been detailed in CMC. The aim of the present study was to assess the prognostic value of NHG, its parameters and NPI. MATERIALS AND METHODS: Univariable and multivariable analyses were used to assess the prognostic value of NHG, its parameters and NPI in a cohort of 59 dogs with CMC. RESULTS: Short disease-free interval and overall survival were associated with higher NHG, particularly of grade III. Only high nuclear pleomorphism score was significantly associated with poor survival. NPI exhibited a strong predictive value for disease progression. CONCLUSION: NHG, nuclear pleomorphism and NPI have prognostic value in CMC. Nuclear pleomorphism is an independent prognostic factor. Evaluation of nuclear pleomorphism should be included in routine pathology reports. Copyright
Authors: Ashley Case; Becky K Brisson; Amy C Durham; Suzanne Rosen; James Monslow; Elizabeth Buza; Pascale Salah; Julie Gillem; Gordon Ruthel; Sridhar Veluvolu; Veronica Kristiansen; Ellen Puré; Dorothy C Brown; Karin U Sørenmo; Susan W Volk Journal: PLoS One Date: 2017-07-06 Impact factor: 3.240
Authors: Suzanne Rosen; Becky K Brisson; Amy C Durham; Clare M Munroe; Conor J McNeill; Darko Stefanovski; Karin U Sørenmo; Susan W Volk Journal: PLoS One Date: 2020-08-10 Impact factor: 3.752