Paolo Tini1, Alfonso Cerase2, Gabriele Cevenini3, Salvatore F Carbone4, Clelia Miracco5, Luigi Pirtoli6. 1. Unit of Radiation Oncology, Le Scotte University Hospital, Siena, Italy paolo-tini@libero.it. 2. Unit of Neuroradiology, Le Scotte University Hospital, Siena, Italy. 3. Section of Biomedical Engineering, University of Siena, Siena, Italy. 4. Unit of Diagnostic Radiology, Le Scotte University Hospital, Siena, Italy. 5. Section of Pathological Anatomy, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy. 6. Unit of Radiation Oncology, Le Scotte University Hospital, Siena, Italy Section of Radiological Sciences, Department of Human Pathology and Oncology, University of Siena, Siena, Italy.
Abstract
AIM: To analyze the correlation between epidermal growth factor receptor (EGFR) expression and clinicoradiological features in patients with glioblastoma. PATIENTS AND METHODS: Select clinical (age, Karnofsky performance status, neurological performance status) and neuroradiological (multiple tumor incidence, peritumoral edema, response to treatment) prognostic variables were correlated with EGFR expression levels estimated on pathological samples in 144 patients who had undergone postoperative radiochemotherapy treatment. RESULTS: Clinical and radiological prognostic parameters, including synchronous multiple tumor, extent of edema, and radiological response after therapy, showed a statistically significant correlation with the EGFR expression score. Patients with a high EGFR expression seemed to present worse cliniconeurological status and radiological features of tumor aggressiveness (higher incidence of multiple tumor, major extent of peritumoral edema and poorer radiological response to treatment). CONCLUSION: A potential correlation between high EGFR expression and aggressive clinical and radiological features of GB seems to exist, leading to worse prognosis in these patients. Copyright
AIM: To analyze the correlation between epidermal growth factor receptor (EGFR) expression and clinicoradiological features in patients with glioblastoma. PATIENTS AND METHODS: Select clinical (age, Karnofsky performance status, neurological performance status) and neuroradiological (multiple tumor incidence, peritumoral edema, response to treatment) prognostic variables were correlated with EGFR expression levels estimated on pathological samples in 144 patients who had undergone postoperative radiochemotherapy treatment. RESULTS: Clinical and radiological prognostic parameters, including synchronous multiple tumor, extent of edema, and radiological response after therapy, showed a statistically significant correlation with the EGFR expression score. Patients with a high EGFR expression seemed to present worse cliniconeurological status and radiological features of tumor aggressiveness (higher incidence of multiple tumor, major extent of peritumoral edema and poorer radiological response to treatment). CONCLUSION: A potential correlation between high EGFR expression and aggressive clinical and radiological features of GB seems to exist, leading to worse prognosis in these patients. Copyright
Authors: Alexandra McAleenan; Claire Kelly; Francesca Spiga; Ashleigh Kernohan; Hung-Yuan Cheng; Sarah Dawson; Lena Schmidt; Tomos Robinson; Sebastian Brandner; Claire L Faulkner; Christopher Wragg; Sarah Jefferies; Amy Howell; Luke Vale; Julian P T Higgins; Kathreena M Kurian Journal: Cochrane Database Syst Rev Date: 2021-03-12
Authors: Samantha N McNulty; Katherine E Schwetye; Cole Ferguson; Chad E Storer; George Ansstas; Albert H Kim; David H Gutmann; Joshua B Rubin; Richard D Head; Sonika Dahiya Journal: Sci Rep Date: 2021-10-08 Impact factor: 4.379