Nicolae Bacalbasa1, Simona Dima2, Irina Balescu3, Leonard David2, Vladislav Brasoveanu2, Irinel Popescu4. 1. Carol Davila University of Medicine and Pharmacy, Bucharest, Romania nicolae_bacalbasa@yahoo.ro. 2. Dan Setlacec Center of Gastrointestinal Disease and Liver Transplantation, Fundeni Clinical Institute, Bucharest, Romania. 3. Ponderas Hospital, Bucharest, Romania. 4. Carol Davila University of Medicine and Pharmacy, Bucharest, Romania Dan Setlacec Center of Gastrointestinal Disease and Liver Transplantation, Fundeni Clinical Institute, Bucharest, Romania.
Abstract
AIM: To determine the impact of maximal cytoreductive surgery on overall survival in advanced epithelial ovarian cancer. PATIENTS AND METHODS: We retrospectively reviewed medical data of patients submitted to primary cytoreductive surgery for advanced epithelial cancer in the Fundeni Clinical Hospital between 1 January 2002 and 1 April 2014. RESULTS: A total of 338 patients were eligible for the study. Complete cytoreduction was achieved in 242 patients and was associated with a significantly improved survival (p<0.001), when compared to patients in whom incomplete debulking surgery was performed. Other prognostic factors associated with an improved survival were stage by the International Federation of Gynecology and Obstetrics and the preoperative biological status of the patient. CONCLUSION: A more extensive surgical approach is perfectly justified and associated with improved survival in patients with advanced-stage epithelial ovarian cancer. However, patient selection should be performed carefully because the general preoperative status can significantly impact survival. Copyright
AIM: To determine the impact of maximal cytoreductive surgery on overall survival in advanced epithelial ovarian cancer. PATIENTS AND METHODS: We retrospectively reviewed medical data of patients submitted to primary cytoreductive surgery for advanced epithelial cancer in the Fundeni Clinical Hospital between 1 January 2002 and 1 April 2014. RESULTS: A total of 338 patients were eligible for the study. Complete cytoreduction was achieved in 242 patients and was associated with a significantly improved survival (p<0.001), when compared to patients in whom incomplete debulking surgery was performed. Other prognostic factors associated with an improved survival were stage by the International Federation of Gynecology and Obstetrics and the preoperative biological status of the patient. CONCLUSION: A more extensive surgical approach is perfectly justified and associated with improved survival in patients with advanced-stage epithelial ovarian cancer. However, patient selection should be performed carefully because the general preoperative status can significantly impact survival. Copyright
Authors: Nicolae Bacalbasa; Camelia Diaconu; Laura Iliescu; Simona Dima; Ovidiu Gabriel Bratu; Dragos Cretoiu; Adrian Neacsu; Alexandru Filipescu; Cornel Savu; Irina Balescu Journal: In Vivo Date: 2020 Sep-Oct Impact factor: 2.155