Roel Henneman1, Hester S Van Monsjou2, Caroline V M Verhagen3, Marie-Louise F Van Velthuysen4, Natalja T Ter Haar5, E Michelle Osse5, Marta I Lopez-Yurda6, Alfons J M Balm7, Michiel W M Van Den Brekel7. 1. Department of Head and Neck Oncology and Surgery, Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands r.henneman@nki.nl. 2. Department of Head and Neck Oncology and Surgery, Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands Department of Otorhinolaryngology, Leiden University Medical Center, Leiden, the Netherlands. 3. Department of Head and Neck Oncology and Surgery, Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands Department of Otorhinolaryngology, University Medical Center St Radboud, Nijmegen, the Netherlands. 4. Department of Pathology, Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands. 5. Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands. 6. Department of Biostatistics, Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands. 7. Department of Head and Neck Oncology and Surgery, Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.
Abstract
AIM: Human papillomavirus (HPV) is a risk factor for oropharyngeal squamous cell carcinoma (OPSCC), with an increasing incidence. The present study aimed to determine the changing incidence of HPV in patients with OPSCC in the period 1980-2009 and its influence on survival. PATIENTS AND METHODS: We randomly sampled 158 patients from a cohort of 828 patients with OPSCC stratified by decade (1980-1989, 1990-1999, 2000-2009). Formalin-fixed paraffin-embedded material was tested for HPV DNA by SPF-10 polymerase chain reaction (PCR) and immunohistochemically stained for p16 and p53. RESULTS: DNA from 146 patients was suitable for HPV detection. HPV DNA was detected in 13/47 (28%), 18/47 (38%), and 20/52 (38%) patients in the cohorts of 1980-1989, 1990-1999, and 2000-2009, respectively (p-value for trend=0.269). Lack of further increase during the most recent decade is inconsistent with the rising incidence and higher prevalence reported in other Western countries. Patients with HPV-positive OPSCC had a better survival in spite of higher tumor stage. Copyright
AIM: Human papillomavirus (HPV) is a risk factor for oropharyngeal squamous cell carcinoma (OPSCC), with an increasing incidence. The present study aimed to determine the changing incidence of HPV in patients with OPSCC in the period 1980-2009 and its influence on survival. PATIENTS AND METHODS: We randomly sampled 158 patients from a cohort of 828 patients with OPSCC stratified by decade (1980-1989, 1990-1999, 2000-2009). Formalin-fixed paraffin-embedded material was tested for HPV DNA by SPF-10 polymerase chain reaction (PCR) and immunohistochemically stained for p16 and p53. RESULTS: DNA from 146 patients was suitable for HPV detection. HPV DNA was detected in 13/47 (28%), 18/47 (38%), and 20/52 (38%) patients in the cohorts of 1980-1989, 1990-1999, and 2000-2009, respectively (p-value for trend=0.269). Lack of further increase during the most recent decade is inconsistent with the rising incidence and higher prevalence reported in other Western countries. Patients with HPV-positive OPSCC had a better survival in spite of higher tumor stage. Copyright
Authors: Farah Succaria; Pia Kvistborg; Suzanne L Topalian; Janis M Taube; Julie E Stein; Elizabeth L Engle; Tracee L McMiller; Lisa M Rooper; Elizabeth Thompson; Alan E Berger; Michiel van den Brekel; Charlotte L Zuur; John Haanen Journal: Cancer Immunol Immunother Date: 2020-10-30 Impact factor: 6.968
Authors: Paula Bos; Michiel W M van den Brekel; Zeno A R Gouw; Abrahim Al-Mamgani; Selam Waktola; Hugo J W L Aerts; Regina G H Beets-Tan; Jonas A Castelijns; Bas Jasperse Journal: Head Neck Date: 2020-10-07 Impact factor: 3.147