Isolated Castleman's disease in the neck.

It can be difficult for the clinician to diagnose Castleman's disease when cervical lymphadenopathy is its only manifestation. The diagnostic challenge may be compounded by the presence of a profound fibrotic reaction secondary to multiple biopsy attempts that are frequently required to establish a diagnosis. Castleman's disease is a benign lymphoproliferative disorder and it most frequently involves the mediastinal lymph nodes. The recognition of an occasional variant of this disorder with a potential malignant course and its association with AIDS calls for a greater awareness of this disease among all clinicians.