Johann Fontana1, Johann Scharf2, Christel Weiß3, Kirsten Schmieder4, Martin Barth5. 1. Department of Neurosurgery, Knappschafts-Krankenhaus Bochum, Ruhr-University Bochum, In der Schornau 23-25, 44892 Bochum, Germany. Electronic address: johann.fontana@kk-bochum.de. 2. Department of Neuroradiology, Paracelsus Clinics, Am Natruper Holz 69, 49076 Osnabrück, Germany. Electronic address: johannscharf@googlemail.com. 3. Department of Medical Statistics, University Medicine Mannheim, Medical Faculty Mannheim of the University of Heidelberg, Ludolf-Krehl-Straße 13-17, D-68167 Mannheim, Germany. Electronic address: christel.weiss@medma.uni-heidelberg.de. 4. Department of Neurosurgery, Knappschafts-Krankenhaus Bochum, Ruhr-University Bochum, In der Schornau 23-25, 44892 Bochum, Germany. Electronic address: kirsten.schmieder@kk-bochum.de. 5. Department of Neurosurgery, Knappschafts-Krankenhaus Bochum, Ruhr-University Bochum, In der Schornau 23-25, 44892 Bochum, Germany. Electronic address: martin.barth@kk-bochum.de.
Abstract
OBJECTIVES: A spontaneous blood pressure (BP) rise is frequently observed after aneurysmal subarachnoid hemorrhage (aSAH). The current study was designed to characterize the time course of this BP rise and its relation to clinical and radiological parameters. METHODS: The diastolic (DBP), mean (MAP), and systolic (SBP) BP values were determined in 61 aSAH patients from day 0 to 9. The patient's initial status was evaluated by the world federation of neurological surgeons scale and the Hijdra scale. The clinical outcome was quantified by the modified Rankin Scale, the Glasgow Outcome Scale Extended, and the National Institute of Health Stroke Scale. The degree of proximal and global vasospasm was calculated by comparison of the baseline angiography on day 0 and the control angiography on day 8. Furthermore, the influence of propofol and norepinephrine application was analyzed. RESULTS: DBP, MAP, and SBP demonstrated an early rise in all patients from day 2 till 5 (p<0.001) and remained hypertensive until day 9. No significant correlation could be detected between this early BP rise and most clinical and radiological variables. From day 8 onwards, a divergence of the SBP courses was detected between patients with severe vs. non-severe global vasospasm. There was a secondary, norepinephrine independent SBP rise in patients with severe global vasospasm that significantly correlated with the initial Hijdra-scale and an unfavorable clinical outcome. CONCLUSIONS: The results demonstrate a biphasic BP course with a uniform early BP rise in all patients and an additional delayed SBP rise in patients with severe global vasospasm.
OBJECTIVES: A spontaneous blood pressure (BP) rise is frequently observed after aneurysmal subarachnoid hemorrhage (aSAH). The current study was designed to characterize the time course of this BP rise and its relation to clinical and radiological parameters. METHODS: The diastolic (DBP), mean (MAP), and systolic (SBP) BP values were determined in 61 aSAH patients from day 0 to 9. The patient's initial status was evaluated by the world federation of neurological surgeons scale and the Hijdra scale. The clinical outcome was quantified by the modified Rankin Scale, the Glasgow Outcome Scale Extended, and the National Institute of Health Stroke Scale. The degree of proximal and global vasospasm was calculated by comparison of the baseline angiography on day 0 and the control angiography on day 8. Furthermore, the influence of propofol and norepinephrine application was analyzed. RESULTS:DBP, MAP, and SBP demonstrated an early rise in all patients from day 2 till 5 (p<0.001) and remained hypertensive until day 9. No significant correlation could be detected between this early BP rise and most clinical and radiological variables. From day 8 onwards, a divergence of the SBP courses was detected between patients with severe vs. non-severe global vasospasm. There was a secondary, norepinephrine independent SBP rise in patients with severe global vasospasm that significantly correlated with the initial Hijdra-scale and an unfavorable clinical outcome. CONCLUSIONS: The results demonstrate a biphasic BP course with a uniform early BP rise in all patients and an additional delayed SBP rise in patients with severe global vasospasm.
Authors: Danny D Dinh; Darcy Lidington; Jeffrey T Kroetsch; Chloe Ng; Hangjun Zhang; Sergei A Nedospasov; Scott P Heximer; Steffen-Sebastian Bolz Journal: Front Physiol Date: 2020-05-13 Impact factor: 4.566
Authors: Corinne Fischer; Johannes Goldberg; Sonja Vulcu; Franca Wagner; Daniel Schöni; Nicole Söll; Matthias Hänggi; Jörg Schefold; Christian Fung; Jürgen Beck; Andreas Raabe; Werner J Z'Graggen Journal: Front Neurol Date: 2019-10-31 Impact factor: 4.003