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Literature DB >> 26123258

Anorexia in human and experimental animal models: physiological aspects related to neuropeptides.

Mitsuhiro Yoshimura¹, Yasuhito Uezono, Yoichi Ueta.

Abstract

Anorexia, a loss of appetite for food, can be caused by various physiological and pathophysiological conditions. In this review, firstly, clinical aspects of anorexia nervosa are summarized in brief. Secondly, hypothalamic neuropeptides responsible for feeding regulation in each hypothalamic nucleus are discussed. Finally, three different types of anorexigenic animal models; dehydration-induced anorexia, cisplatin-induced anorexia and cancer anorexia-cachexia, are introduced. In conclusion, hypothalamic neuropeptides may give us novel insight to understand and find effective therapeutics strategy essential for various kinds of anorexia.

Entities: Chemical Disease Species

Mesh：

Substances：
Neuropeptides
Cisplatin

Year: 2015 PMID： 26123258 DOI： 10.1007/s12576-015-0386-3

Source DB: PubMed Journal: J Physiol Sci ISSN： 1880-6546 Impact factor: 2.781

129 in total

1. Reduced feeding during water deprivation depends on hydration of the gut.

Authors: Guus H M Schoorlemmer; Mark D Evered
Journal: Am J Physiol Regul Integr Comp Physiol Date: 2002-11 Impact factor: 3.619

2. Changes in the melanocortin receptors in the hypothalamus of a rat model of cancer cachexia.

Authors: Masami Suzuki; Minoru Narita; Maho Ashikawa; Sadayoshi Furuta; Motohiro Matoba; Hiroki Sasaki; Kazuyoshi Yanagihara; Kiyoshi Terawaki; Tsutomu Suzuki; Yasuhito Uezono
Journal: Synapse Date: 2012-04-17 Impact factor: 2.562

3. Parathyroid hormone-related protein induces cachectic syndromes without directly modulating the expression of hypothalamic feeding-regulating peptides.

Authors: Hirofumi Hashimoto; Yumiko Azuma; Makoto Kawasaki; Hiroaki Fujihara; Etsuro Onuma; Hisafumi Yamada-Okabe; Yoh Takuwa; Etsuro Ogata; Yoichi Ueta
Journal: Clin Cancer Res Date: 2007-01-01 Impact factor: 12.531

4. Involvement of parathyroid hormone-related protein in experimental cachexia induced by a human lung cancer-derived cell line established from a bone metastasis specimen.

Authors: H Iguchi; E Onuma; K Sato; K Sato; E Ogata
Journal: Int J Cancer Date: 2001-10-01 Impact factor: 7.396

5. Topographic mapping of VMH --> arcuate nucleus microcircuits and their reorganization by fasting.

Authors: Scott M Sternson; Gordon M G Shepherd; Jeffrey M Friedman
Journal: Nat Neurosci Date: 2005-09-18 Impact factor: 24.884

6. Cachexia in MAC16 adenocarcinoma: suppression of hunger despite normal regulation of leptin, insulin and hypothalamic neuropeptide Y.

Authors: C Bing; S Taylor; M J Tisdale; G Williams
Journal: J Neurochem Date: 2001-12 Impact factor: 5.372

Review 5. Somato-axodendritic release of oxytocin into the brain due to calcium amplification is essential for social memory.

Authors: Haruhiro Higashida
Journal: J Physiol Sci Date: 2015-11-19 Impact factor: 2.781

Review 6. Cancer cachexia and its pathophysiology: links with sarcopenia, anorexia and asthenia.

Authors: Sara Peixoto da Silva; Joana M O Santos; Maria Paula Costa E Silva; Rui M Gil da Costa; Rui Medeiros
Journal: J Cachexia Sarcopenia Muscle Date: 2020-03-06 Impact factor: 12.910

6 in total

Anorexia in human and experimental animal models: physiological aspects related to neuropeptides.

1. Reduced feeding during water deprivation depends on hydration of the gut.

2. Changes in the melanocortin receptors in the hypothalamus of a rat model of cancer cachexia.

3. Parathyroid hormone-related protein induces cachectic syndromes without directly modulating the expression of hypothalamic feeding-regulating peptides.

4. Involvement of parathyroid hormone-related protein in experimental cachexia induced by a human lung cancer-derived cell line established from a bone metastasis specimen.

5. Topographic mapping of VMH --> arcuate nucleus microcircuits and their reorganization by fasting.

6. Cachexia in MAC16 adenocarcinoma: suppression of hunger despite normal regulation of leptin, insulin and hypothalamic neuropeptide Y.

Review 7. Prevention and treatment of cancer cachexia: new insights into an old problem.

8. Assessment of feeding response of tumor-bearing rats to hypothalamic injection and infusion of neuropeptide Y.

9. Hypothalamic control of food intake in rats and cats.

10. Potentiation of ghrelin signaling attenuates cancer anorexia-cachexia and prolongs survival.

Review 1. Expanding frontiers in weight-control research explored by young investigators.

2. Inhibition of ghrelin-induced feeding in rats by pretreatment with a novel dual orexin receptor antagonist.

Review 3. Peripheral Vascular Abnormalities in Anorexia Nervosa: A Psycho-Neuro-Immune-Metabolic Connection.

4. Arginine vasopressin: Direct and indirect action on metabolism.

Review 5. Somato-axodendritic release of oxytocin into the brain due to calcium amplification is essential for social memory.

Review 6. Cancer cachexia and its pathophysiology: links with sarcopenia, anorexia and asthenia.