Literature DB >> 2612217

Loss of heterozygosity in human germinal tumors.

P Radice1, M A Pierotti, S Lacerenza, P Mondini, M T Radice, S Pilotti, G Della Porta.   

Abstract

The frequency of losses of heterozygosity has been investigated in 14 germinal tumors of the testis. Nonrandom deletion of whole or part of chromosome 11 was observed in four cases. In addition, loss of heterozygosity of all the informative loci analyzed was detected in one ovarian teratoma, indicating its post-meiotic origin. These results suggest that different genetic mechanisms (chromosomal deletions or meiotic segregation) that unmask putative recessive mutations are involved in the onset of germinal tumors.

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Year:  1989        PMID： 2612217     DOI： 10.1159/000132843

Source DB:  PubMed          Journal:  Cytogenet Cell Genet        ISSN： 0301-0171


  6 in total

1.  Frequent homozygosity in both mature and immature ovarian teratomas: a shared genetic basis of tumorigenesis.

Authors:  Olivia L Snir; Maura DeJoseph; Serena Wong; Natalia Buza; Pei Hui
Journal:  Mod Pathol       Date:  2017-06-30       Impact factor: 7.842

Review 2.  Molecular biology of testicular germ cell tumors: current status.

Authors:  B Schmidt; R Ackermann; T Strohmeyer
Journal:  J Mol Med (Berl)       Date:  1995-07       Impact factor: 4.599

3.  Loss of heterozygosity involving the APC and MCC genetic loci occurs in the majority of human esophageal cancers.

Authors:  R F Boynton; P L Blount; J Yin; V L Brown; Y Huang; Y Tong; T McDaniel; C Newkirk; J H Resau; W H Raskind; R C Haggitt; B J Reid; S J Meltzer
Journal:  Proc Natl Acad Sci U S A       Date:  1992-04-15       Impact factor: 11.205

4.  Three tumor-suppressor regions on chromosome 11p identified by high-resolution deletion mapping in human non-small-cell lung cancer.

Authors:  G Bepler; M A Garcia-Blanco
Journal:  Proc Natl Acad Sci U S A       Date:  1994-06-07       Impact factor: 11.205

5.  Transcriptional map of 170-kb region at chromosome 11p15.5: identification and mutational analysis of the BWR1A gene reveals the presence of mutations in tumor samples.

Authors:  C Schwienbacher; S Sabbioni; M Campi; A Veronese; G Bernardi; A Menegatti; I Hatada; T Mukai; H Ohashi; G Barbanti-Brodano; C M Croce; M Negrini
Journal:  Proc Natl Acad Sci U S A       Date:  1998-03-31       Impact factor: 11.205

Review 6.  Molecular characteristics of malignant ovarian germ cell tumors and comparison with testicular counterparts: implications for pathogenesis.

Authors:  Sigrid Marie Kraggerud; Christina E Hoei-Hansen; Sharmini Alagaratnam; Rolf I Skotheim; Vera M Abeler; Ewa Rajpert-De Meyts; Ragnhild A Lothe
Journal:  Endocr Rev       Date:  2013-04-10       Impact factor: 19.871
  6 in total

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