Nirav T Potana1, Ashish R Dongara, Somashekhar M Nimbalkar, Dipen V Patel, Archana S Nimbalkar, Ajay Phatak. 1. Departments of Pediatrics and *Physiology, Pramukhswami Medical College; and #Central Research Services, Charutar Arogya Mandal; Karamsad, Gujarat, India. Correspondence to: Prof Somashekhar Nimbalkar, Professor of Pediatrics, Department of Pediatrics, Pramukhswami Medical College, Karamsad-Anand, Gujarat 388 325. somu_somu@yahoo.com.
Abstract
OBJECTIVE: To test the efficacy of oral sucrose in reducing pain/stress during echocardiography as estimated by Premature Infant Pain Profile score. DESIGN: Double-blind, parallel-group, randomized control trial. SETTING: Tertiary-care neonatal care unit located in Western India. PARTICIPANTS: Neonates with established enteral feeding, not on any respiratory support and with gestational age between 32 and 42 weeks requiring echocardiography. INTERVENTIONS: Neonates in intervention group received oral sucrose prior to echocardiography. MAIN OUTCOME MEASURES: Assessment was done using Premature Infant Pain Profile score. RESULTS: There were 104 examinations; 52 in each group. Baseline characteristics like mean gestational age (37.6 vs. 37.1), birth weight (2.20 vs. 2.08), and feeding status (Breastfeeding- 59.6% vs. 44.2%, paladai feeding- 13.5% vs. 13.5%, and gavage feeding- 26.9% vs. 42.3%) were comparable. The mean (SD) premature infant pain profile score was significantly higher in control group [(7.4 (3.78) vs. 5.2 (1.92), P <0.001]. CONCLUSION:Oral sucrose significantly reduces pain, and is safe to administer to neonates.
RCT Entities:
OBJECTIVE: To test the efficacy of oral sucrose in reducing pain/stress during echocardiography as estimated by Premature InfantPain Profile score. DESIGN: Double-blind, parallel-group, randomized control trial. SETTING: Tertiary-care neonatal care unit located in Western India. PARTICIPANTS: Neonates with established enteral feeding, not on any respiratory support and with gestational age between 32 and 42 weeks requiring echocardiography. INTERVENTIONS: Neonates in intervention group received oral sucrose prior to echocardiography. MAIN OUTCOME MEASURES: Assessment was done using Premature InfantPain Profile score. RESULTS: There were 104 examinations; 52 in each group. Baseline characteristics like mean gestational age (37.6 vs. 37.1), birth weight (2.20 vs. 2.08), and feeding status (Breastfeeding- 59.6% vs. 44.2%, paladai feeding- 13.5% vs. 13.5%, and gavage feeding- 26.9% vs. 42.3%) were comparable. The mean (SD) premature infantpain profile score was significantly higher in control group [(7.4 (3.78) vs. 5.2 (1.92), P <0.001]. CONCLUSION: Oral sucrose significantly reduces pain, and is safe to administer to neonates.
Authors: Arindrajit Ganguly; Pranav J Bhadesia; Ajay G Phatak; Archana S Nimbalkar; Somashekhar M Nimbalkar Journal: J Family Med Prim Care Date: 2020-03-26