Literature DB >> 26121554

MgI2 -mediated chemoselective cleavage of protecting groups: an alternative to conventional deprotection methodologies.

Mathéo Berthet1, Florian Davanier1, Gilles Dujardin2, Jean Martinez1, Isabelle Parrot3.   

Abstract

The scope of MgI2 as a valuable tool for quantitative and mild chemoselective cleavage of protecting groups is described here. This novel synthetic approach expands the use of protecting groups, widens the concept of orthogonality in synthetic processes, and offers a facile opportunity to release compounds from solid supports.
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Keywords:  carbamates; cleavage reactions; esters; protecting groups; solid-phase synthesis

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Year:  2015        PMID: 26121554     DOI: 10.1002/chem.201501799

Source DB:  PubMed          Journal:  Chemistry        ISSN: 0947-6539            Impact factor:   5.236


  1 in total

1.  Efficient Fmoc-Protected Amino Ester Hydrolysis Using Green Calcium(II) Iodide as a Protective Agent.

Authors:  Renaud Binette; Michael Desgagné; Camille Theaud; Pierre-Luc Boudreault
Journal:  Molecules       Date:  2022-04-27       Impact factor: 4.927

  1 in total

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