Literature DB >> 2612155

Transforming growth factor beta mediates the estrogen induced inhibition of UMR106 cell growth.

T K Gray1, B Lipes, T Linkhart, S Mohan, D Baylink.   

Abstract

A mitogenic response to transforming growth factor beta (TGF) occurred in the UMR106 cells cultured in serum-free medium and exposed serially to estradiol and TGF. This mitogenic response was lost when insulin was removed from the medium. TGF inhibited growth and increased the alkaline phosphatase content in the UMR106 cells cultured in medium lacking insulin. Prior exposure of the cells to estradiol enhanced this response. Monoclonal antibodies against TGF blocked the estradiol induced inhibition of growth after a two day incubation in medium devoid of insulin.

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Year:  1989        PMID： 2612155     DOI： 10.3109/03008208909023871

Source DB:  PubMed          Journal:  Connect Tissue Res        ISSN： 0300-8207            Impact factor:   3.417


  6 in total

1.  Influence of temperature on the proliferative response of rainbow trout gonadal fibroblasts to cortisol and RU 486.

Authors:  J A Van Oostrom; N C Bols
Journal:  Fish Physiol Biochem       Date:  1991-06       Impact factor: 2.794

2.  The expression of transforming growth factor-beta and interleukin-1beta mRNA and the response to 1,25(OH)2D3' 17 beta-estradiol, and testosterone is age dependent in primary cultures of mouse-derived osteoblasts in vitro.

Authors:  X Wang; Z Schwartz; P Yaffe; A Ornoy
Journal:  Endocrine       Date:  1999-08       Impact factor: 3.633

3.  Transforming growth factor-beta1 modulates chondrocyte responsiveness to 17beta-estradiol.

Authors:  E Nasatzky; D Grinfeld; B D Boyan; D D Dean; A Ornoy; Z Schwartz
Journal:  Endocrine       Date:  1999-12       Impact factor: 3.633

4.  The effects of 17 beta-estradiol on chondrocyte differentiation are modulated by vitamin D3 metabolites.

Authors:  Z Schwartz; Y Finer; E Nasatzky; W A Soskolne; D D Dean; B D Boyan; A Ornoy
Journal:  Endocrine       Date:  1997-10       Impact factor: 3.633

5.  Estrogen prevents bone loss through transforming growth factor beta signaling in T cells.

Authors:  Yuhao Gao; Wei-Ping Qian; Kimberly Dark; Gianluca Toraldo; Angela S P Lin; Robert E Guldberg; Richard A Flavell; M Neale Weitzmann; Roberto Pacifici
Journal:  Proc Natl Acad Sci U S A       Date:  2004-11-05       Impact factor: 11.205

6.  Ovariectomy selectively reduces the concentration of transforming growth factor beta in rat bone: implications for estrogen deficiency-associated bone loss.

Authors:  R D Finkelman; N H Bell; D D Strong; L M Demers; D J Baylink
Journal:  Proc Natl Acad Sci U S A       Date:  1992-12-15       Impact factor: 11.205
  6 in total

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