Paul L Wood1. 1. Metabolomics Unit, Dept. of Physiology and Pharmacology, DeBusk College of Osteopathic Medicine, Lincoln Memorial University, 6965 Cumberland Gap Pkwy, Harrogate, TN.
Abstract
BACKGROUND: While schizophrenia is generally considered a neurodevelopment disorder, our basic understanding of the biochemical processes involved in disease etiology and/or progression is limited. One class of biochemical mediators that has been suggested to play a role in the development of schizophrenia is N-acyl ethanolamine metabolites of N-acylphosphatidylethanolamines. However, no investigations of N-acylphosphatidylserines or their N-acylserine metabolites have been published. METHODS: We undertook a targeted postmortem lipidomics analysis of N-acylphosphatidylserines (NAPS) and N-acylserines (NAS) in gray matter of the frontal cortex of schizophrenia subjects. RESULTS: Our data are the first to demonstrate that NAPS and NAS are present in human brain. Furthermore, NAPS and their bioactive metabolites, N-acylserines (NAS), were found to be significantly elevated in the frontal cortex of schizophrenia subjects. CONCLUSIONS: Elevated levels of NAPS lipid pools in schizophrenia may result in complex alterations in the structural function of neuronal membranes while increases in NAS may alter signal transduction pathways.
n class="abstract_title">BACKGROUND: While schizophrenia is generally considered a neurodevelopment disorder, our basic understanding of the biochemical processes involved in disease etiology and/or progression is limited. One class of biochemical mediators that has been suggested to play a role in the development of schizophrenia is N-acyl ethanolamine metabolites of N-acylphosphatidylethanolamines. However, no investigations of N-acylphosphatidylserines or their N-acylserine metabolites have been published. METHODS: We undertook a targeted postmortem lipidomics analysis of N-acylphosphatidylserines (NAPS) and N-acylserines (NAS) in gray matter of the frontal cortex of schizophrenia subjects. RESULTS: Our data are the first to demonstrate that NAPS and NAS are present in human brain. Furthermore, NAPS and their bioactive metabolites, N-acylserines (NAS), were found to be significantly elevated in the frontal cortex of schizophrenia subjects. CONCLUSIONS: Elevated levels of NAPSlipid pools in schizophrenia may result in complex alterations in the structural function of neuronal membranes while increases in NAS may alter signal transduction pathways.
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