Christine Sempoux1, Valérie Paradis2, Mina Komuta3, Aileen Wee4, Julien Calderaro5, Charles Balabaud6, Alberto Quaglia7, Paulette Bioulac-Sage8. 1. Service d'Anatomie pathologique, Cliniques universitaires Saint-Luc, Avenue Hippocrate, 10, B-1200 Brussels, Belgium. 2. Inserm UMR 1149, Université Paris Diderot, Department of Pathology, Beaujon Hospital, 92110 Clichy, France. 3. Translational Cell & Tissue Research Unit, Department of Imaging & Pathology, K.U. Leuven, Minderbroedersstraat 12, Leuven 3000, Belgium. 4. Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, National University Hospital, Singapore 119074, Singapore. 5. Department of Pathology, Assistance Publique-Hôpitaux de Paris, Centre Hospitalier Universitaire Henri Mondor, 94000 Créteil, France; INSERM, U955, Institut Mondor de Recherche Biomédicale, 94010 Créteil, France. 6. Inserm, UMR 1053, Université de Bordeaux, Bordeaux F-33076, France. 7. Institute of Liver Studies, King's College Hospital, London, UK. 8. Inserm, UMR 1053, Université de Bordeaux, Bordeaux F-33076, France; Department of Pathology, Pellegrin Hospital, Centre Hospitalier Universitaire Bordeaux, F-33076, France. Electronic address: paulette.bioulac-sage@u-bordeaux.fr.
Abstract
BACKGROUND & AIMS: A broad range of hepatocellular nodules has been reported in hepatic vascular disorders. It is not clear whether hepatocellular adenoma (HCA) in this context share the same characteristics as conventional HCA. The aim of this study was to carry out a retrospective multicenter survey of hepatocellular nodules associated with hepatic vascular disorders. METHODS: Forty-five cases were reviewed, including 32 Budd-Chiari syndrome (BCS). Benign nodules were subtyped using the HCA immunohistochemical panel. RESULTS: Nodules with a HCA morphology were observed in 11 cases. Six originated in BCS: two were liver fatty acid binding protein (LFABP) negative (one with malignant transformation); two expressed glutamine synthetase (GS) and nuclear b-catenin, two expressed C reactive protein (CRP). Among three cases with portal vein agenesis, one nodule was LFABP negative, two expressed GS and nuclear b-catenin, both with malignant transformation. In a Fallot tetralogy case, there were multiple LFABP negative nodules with borderline features and in a hepatoportal sclerosis case, the nodule looked like an inflammatory HCA. Two additional cases had nodules expressing CRP, without typical characteristics of inflammatory HCA. CONCLUSION: HCA of different immunohistochemical phenotype can develop in hepatic vascular disorders; they may have a different behavior compared to conventional HCA and be more at risk of malignant transformation.
BACKGROUND & AIMS: A broad range of hepatocellular nodules has been reported in hepatic vascular disorders. It is not clear whether hepatocellular adenoma (HCA) in this context share the same characteristics as conventional HCA. The aim of this study was to carry out a retrospective multicenter survey of hepatocellular nodules associated with hepatic vascular disorders. METHODS: Forty-five cases were reviewed, including 32 Budd-Chiari syndrome (BCS). Benign nodules were subtyped using the HCA immunohistochemical panel. RESULTS: Nodules with a HCA morphology were observed in 11 cases. Six originated in BCS: two were liver fatty acid binding protein (LFABP) negative (one with malignant transformation); two expressed glutamine synthetase (GS) and nuclear b-catenin, two expressed C reactive protein (CRP). Among three cases with portal vein agenesis, one nodule was LFABP negative, two expressed GS and nuclear b-catenin, both with malignant transformation. In a Fallot tetralogy case, there were multiple LFABP negative nodules with borderline features and in a hepatoportal sclerosis case, the nodule looked like an inflammatory HCA. Two additional cases had nodules expressing CRP, without typical characteristics of inflammatory HCA. CONCLUSION: HCA of different immunohistochemical phenotype can develop in hepatic vascular disorders; they may have a different behavior compared to conventional HCA and be more at risk of malignant transformation.
Authors: Juan Putra; Linda D Ferrell; Annette S H Gouw; Valerie Paradis; Arvind Rishi; Christine Sempoux; Charles Balabaud; Swan N Thung; Paulette Bioulac-Sage Journal: Mod Pathol Date: 2019-09-30 Impact factor: 7.842
Authors: Frank DiPaola; Andrew T Trout; Ashley E Walther; Anita Gupta; Rachel Sheridan; Kathleen M Campbell; Greg Tiao; Jorge A Bezerra; Kevin E Bove; Manish Patel; Jaimie D Nathan Journal: Dig Dis Sci Date: 2019-09-23 Impact factor: 3.199
Authors: Ji Hun Kang; Do Hyung Kim; So Yeon Kim; Hyo Jeong Kang; Jung Bok Lee; Kyoung Won Kim; Seung Soo Lee; Jonggi Choi; Young-Suk Lim Journal: Abdom Radiol (NY) Date: 2020-10-23