BACKGROUND: The aim of the present study was to investigate the combined effects of sex hormone-binding globulin (SHBG) and sex hormones on the risk of type 2 diabetes (T2D). METHODS: A nested case-control study of Chinese participants in the Environment, Inflammation and Metabolic Diseases Study (2008-13) was performed. Of the 3510 subjects free of diabetes, 145 men and 87 women developed diabetes over the 5-year follow-up. One age- and sex-matched control subject was selected for each case. Baseline concentrations of SHBG, estradiol, testosterone, and dehydroepiandrosterone sulfate (DHEA-S) were divided into tertiles and subjects were classified as having low, intermediate and high levels accordingly. RESULTS: After multivariate adjustment, men with low SHBG levels had a fourfold greater risk of T2D than men with high SHBG levels. Conversely, men with high estradiol levels had a fourfold greater risk of T2D than men with low estradiol levels. Men with low SHBG + high estradiol had a 20-fold greater risk of T2D than men with high SHBG + low estradiol (odds ratio [OR] 20.23; 95% confidence interval [CI] 4.62-51.33). These risk associations in men were not observed for testosterone or DHEA-S, alone or in combination with SHBG. Compared with low SHBG, the risk of T2D decreased with increasing SHBG tertile (OR 0.92 [95% CI 0.21-4.53], 0.14 [95% CI 0.10-0.74]; Ptrend = 0.043) after multivariate adjustment in women. Estradiol, testosterone, and DHEA-S levels showed no association with T2D in women. CONCLUSION: Low SHBG in conjunction with high estradiol has an additive detrimental effect on the risk of T2D in men.
BACKGROUND: The aim of the present study was to investigate the combined effects of sex hormone-binding globulin (SHBG) and sex hormones on the risk of type 2 diabetes (T2D). METHODS: A nested case-control study of Chinese participants in the Environment, Inflammation and Metabolic Diseases Study (2008-13) was performed. Of the 3510 subjects free of diabetes, 145 men and 87 women developed diabetes over the 5-year follow-up. One age- and sex-matched control subject was selected for each case. Baseline concentrations of SHBG, estradiol, testosterone, and dehydroepiandrosterone sulfate (DHEA-S) were divided into tertiles and subjects were classified as having low, intermediate and high levels accordingly. RESULTS: After multivariate adjustment, men with low SHBG levels had a fourfold greater risk of T2D than men with high SHBG levels. Conversely, men with high estradiol levels had a fourfold greater risk of T2D than men with low estradiol levels. Men with low SHBG + high estradiol had a 20-fold greater risk of T2D than men with high SHBG + low estradiol (odds ratio [OR] 20.23; 95% confidence interval [CI] 4.62-51.33). These risk associations in men were not observed for testosterone or DHEA-S, alone or in combination with SHBG. Compared with low SHBG, the risk of T2D decreased with increasing SHBG tertile (OR 0.92 [95% CI 0.21-4.53], 0.14 [95% CI 0.10-0.74]; Ptrend = 0.043) after multivariate adjustment in women. Estradiol, testosterone, and DHEA-S levels showed no association with T2D in women. CONCLUSION: Low SHBG in conjunction with high estradiol has an additive detrimental effect on the risk of T2D in men.
Authors: Katherine E Joyce; Mary L Biggs; Luc Djoussé; Joachim H Ix; Jorge R Kizer; David S Siscovick; Molly M Shores; Alvin M Matsumoto; Kenneth J Mukamal Journal: J Clin Endocrinol Metab Date: 2017-01-01 Impact factor: 5.958
Authors: Vanita R Aroda; Costas A Christophi; Sharon L Edelstein; Leigh Perreault; Catherine Kim; Sherita H Golden; Edward Horton; Kieren J Mather Journal: BMJ Open Diabetes Res Care Date: 2020-12
Authors: Aleksandra Biernacka-Bartnik; Piotr Kocełak; Aleksander Jerzy Owczarek; Piotr Choręza; Monika Puzianowska-Kuźnicka; Leszek Markuszewski; Paweł Madej; Jerzy Chudek; Magdalena Olszanecka-Glinianowicz Journal: Int J Endocrinol Date: 2022-01-31 Impact factor: 3.257