Literature DB >> 26118952

Targeting the inflammasome in rheumatic diseases.

Sara S McCoy1, Jasmine Stannard2, J Michelle Kahlenberg3.   

Abstract

Activation of the inflammasome, a protein complex responsible for many cellular functions, including the activation of the proinflammatory cytokines interleukin (IL)-1β and IL-18, has been identified as a key participant in many rheumatic diseases including autoimmune, inflammatory, and autoinflammatory syndromes. This review will discuss the recent advances in understanding the role of this complex in various rheumatic diseases. Furthermore, it will focus on available therapies, which directly and indirectly target the inflammasome and its downstream cytokines to quiet inflammation and possibly dampen autoimmune processes.
Copyright © 2016 Elsevier Inc. All rights reserved.

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Year:  2015        PMID： 26118952      PMCID： PMC4487391          DOI： 10.1016/j.trsl.2015.06.006

Source DB:  PubMed          Journal:  Transl Res        ISSN： 1878-1810            Impact factor:   7.012


  169 in total

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Authors:  Ariel C Bulua; Douglas B Mogul; Ivona Aksentijevich; Harjot Singh; David Y He; Larry R Muenz; Michael M Ward; Cheryl H Yarboro; Daniel L Kastner; Richard M Siegel; Keith M Hull
Journal:  Arthritis Rheum       Date:  2012-03

2.  Blood and synovial fluid cytokine signatures in patients with juvenile idiopathic arthritis: a cross-sectional study.

Authors:  Wilco de Jager; Esther P A H Hoppenreijs; Nico M Wulffraat; Lucy R Wedderburn; Wietse Kuis; Berent J Prakken
Journal:  Ann Rheum Dis       Date:  2006-12-14       Impact factor: 19.103

3.  Inflammasome-independent role of apoptosis-associated speck-like protein containing a CARD (ASC) in T cell priming is critical for collagen-induced arthritis.

Authors:  Sirish K Ippagunta; David D Brand; Jiwen Luo; Kelli L Boyd; Christopher Calabrese; Rinke Stienstra; Frank L Van de Veerdonk; Mihai G Netea; Leo A B Joosten; Mohamed Lamkanfi; Thirumala-Devi Kanneganti
Journal:  J Biol Chem       Date:  2010-02-22       Impact factor: 5.157

4.  Osteolytic lesion in PAPA syndrome responding to anti-interleukin 1 treatment.

Authors:  Roberta Caorsi; Paolo Picco; Antonella Buoncompagni; Alberto Martini; Marco Gattorno
Journal:  J Rheumatol       Date:  2014-11       Impact factor: 4.666

5.  Netting neutrophils induce endothelial damage, infiltrate tissues, and expose immunostimulatory molecules in systemic lupus erythematosus.

Authors:  Eneida Villanueva; Srilakshmi Yalavarthi; Celine C Berthier; Jeffrey B Hodgin; Ritika Khandpur; Andrew M Lin; Cory J Rubin; Wenpu Zhao; Stephen H Olsen; Matthew Klinker; David Shealy; Michael F Denny; Joel Plumas; Laurence Chaperot; Matthias Kretzler; Allen T Bruce; Mariana J Kaplan
Journal:  J Immunol       Date:  2011-05-25       Impact factor: 5.422

6.  A role for mitochondria in NLRP3 inflammasome activation.

Authors:  Rongbin Zhou; Amir S Yazdi; Philippe Menu; Jürg Tschopp
Journal:  Nature       Date:  2010-12-01       Impact factor: 49.962

7.  Genetic variants in CARD8 but not in NLRP3 are associated with ankylosing spondylitis.

Authors:  A Kastbom; E Klingberg; D Verma; H Carlsten; H Forsblad-d'Elia; J Wesamaa; J Cedergren; P Eriksson; P Söderkvist
Journal:  Scand J Rheumatol       Date:  2013-04-02       Impact factor: 3.641

8.  Cyclooxygenase-2 regulates NLRP3 inflammasome-derived IL-1β production.

Authors:  Kuo-Feng Hua; Ju-Ching Chou; Shuk-Man Ka; Yu-Ling Tasi; Ann Chen; Shih-Hsiung Wu; Hsiao-Wen Chiu; Wei-Ting Wong; Yih-Fuh Wang; Change-Ling Tsai; Chen-Lung Ho; Cheng-Hsiu Lin
Journal:  J Cell Physiol       Date:  2015-04       Impact factor: 6.384

9.  Ancient missense mutations in a new member of the RoRet gene family are likely to cause familial Mediterranean fever. The International FMF Consortium.

Authors: 
Journal:  Cell       Date:  1997-08-22       Impact factor: 41.582

10.  Anti-TNF treatment response in rheumatoid arthritis patients is associated with genetic variation in the NLRP3-inflammasome.

Authors:  Jacob Sode; Ulla Vogel; Steffen Bank; Paal Skytt Andersen; Marianne Kragh Thomsen; Merete Lund Hetland; Henning Locht; Niels H H Heegaard; Vibeke Andersen
Journal:  PLoS One       Date:  2014-06-26       Impact factor: 3.240
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  7 in total

Review 1.  Anti-inflammatory panacea? The expanding therapeutics of interleukin-1 blockade.

Authors:  J Michelle Kahlenberg
Journal:  Curr Opin Rheumatol       Date:  2016-05       Impact factor: 5.006

Review 2.  How Pyroptosis Contributes to Inflammation and Fibroblast-Macrophage Cross-Talk in Rheumatoid Arthritis.

Authors:  Benjamin Demarco; Sara Danielli; Fabian A Fischer; Jelena S Bezbradica
Journal:  Cells       Date:  2022-04-12       Impact factor: 7.666

Review 3.  [Caspase-1 regulates autoinflammation in rheumatic diseases].

Authors:  S Winkler; C M Hedrich; A Rösen-Wolff
Journal:  Z Rheumatol       Date:  2016-04       Impact factor: 1.372

4.  A Transcriptional Regulatory Role for the Membrane Type-1 Matrix Metalloproteinase in Carcinogen-Induced Inflammasome Gene Expression.

Authors:  Samuel Sheehy; Borhane Annabi
Journal:  Gene Regul Syst Bio       Date:  2017-06-08

Review 5.  Purinergic signalling in autoimmunity: A role for the P2X7R in systemic lupus erythematosus?

Authors:  Francesco Di Virgilio; Anna Lisa Giuliani
Journal:  Biomed J       Date:  2016-10-27       Impact factor: 4.910

Review 6.  Biologic disease modifying antirheumatic drugs and Janus kinase inhibitors in paediatric rheumatology - what we know and what we do not know from randomized controlled trials.

Authors:  Tatjana Welzel; Carolyn Winskill; Nancy Zhang; Andreas Woerner; Marc Pfister
Journal:  Pediatr Rheumatol Online J       Date:  2021-03-25       Impact factor: 3.054

Review 7.  Management of Monogenic IL-1 Mediated Autoinflammatory Diseases in Childhood.

Authors:  Tatjana Welzel; Susanne M Benseler; Jasmin B Kuemmerle-Deschner
Journal:  Front Immunol       Date:  2021-03-18       Impact factor: 7.561
  7 in total

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