Anja Tzschoppe1, Christina Riedel2, Rüdiger von Kries2, Ellen Struwe3, Wolfgang Rascher1, Helmuth G Dörr1, Matthias W Beckmann4, Ralf L Schild5, Tamme W Goecke6, Allan Flyvbjerg7, Jan Frystyk7, Jörg Dötsch8. 1. Department of Paediatrics and Adolescent Medicine, University of Erlangen-Nuremberg, Erlangen, Germany. 2. Institute of Social Paediatrics and Adolescent Medicine, University of Munich, Munich, Germany. 3. Regional Centre for Social Paediatrics, Klinikum Konstanz, Konstanz, Germany. 4. Department of Obstetrics and Gynaecology, University of Erlangen-Nuremberg, Erlangen, Germany. 5. Department of Obstetrics and Gynaecology, Diakonische Dienste Hannover, Hannover, Germany. 6. Department of Obstetrics and Gynaecology, University of Aachen, Aachen, Germany. 7. Medical Research Laboratory, Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark. 8. Department of Paediatrics and Adolescent Medicine, University of Cologne, Cologne, Germany.
Abstract
OBJECTIVE: Alterations in the growth hormone-insulin-like growth factor (IGF) axis have been considered as a causal factor for intrauterine growth restriction (IUGR) and for the increased risk of metabolic disease in later life. We compared members of the IGF axis in umbilical cord blood between IUGR neonates, small for gestational age without foetal restriction (SGA) and appropriate for gestational age (AGA) neonates. DESIGN: Prospective controlled multicenter study. PATIENTS: Sixteen ultrasound-proven IUGR, 8 SGA and 40 AGA neonates. MEASUREMENTS: Concentrations of total IGF-I and total IGF-II by immunoassays, bioactive IGF by cell-based bioassay and IGFBP-I in mixed venous and arterial umbilical cord blood samples at birth. Auxological parameters at birth. RESULTS: IGF-I concentrations in IUGR [17·7 μg/l (CI 13·8;21·6)] were clearly below those in AGA [48·3 μg/l (CI 43·7;52·9)] and SGA neonates [36·0 μg/l (CI 26·6;45·4)]. IGF-II levels were significantly reduced in IUGR [201·4 μg/l (CI 190·2;212·6)] compared to AGA neonates [231·2 μg/l (CI 220·6;241·9)]. A trend for lower IGF-II concentrations was observed in IUGR when compared to SGA neonates [232·0 μg/l (CI 207·2;256·8)]. These differences could not be explained by confounding. For IGFBP-1, a trend towards higher values in IUGR was observed. CONCLUSIONS: Low IGF-I cord blood concentrations in hypotrophic neonates after IUGR might not only result from low birthweight per se, but also reflect prenatal placental environment. Alterations of the IGF axis could be in the causal pathway of IUGR and thus constitute a potential surrogate marker for IUGR in the assessment of foetal programming.
OBJECTIVE: Alterations in the growth hormone-insulin-like growth factor (IGF) axis have been considered as a causal factor for intrauterine growth restriction (IUGR) and for the increased risk of metabolic disease in later life. We compared members of the IGF axis in umbilical cord blood between IUGR neonates, small for gestational age without foetal restriction (SGA) and appropriate for gestational age (AGA) neonates. DESIGN: Prospective controlled multicenter study. PATIENTS: Sixteen ultrasound-proven IUGR, 8 SGA and 40 AGA neonates. MEASUREMENTS: Concentrations of total IGF-I and total IGF-II by immunoassays, bioactive IGF by cell-based bioassay and IGFBP-I in mixed venous and arterial umbilical cord blood samples at birth. Auxological parameters at birth. RESULTS:IGF-I concentrations in IUGR [17·7 μg/l (CI 13·8;21·6)] were clearly below those in AGA [48·3 μg/l (CI 43·7;52·9)] and SGA neonates [36·0 μg/l (CI 26·6;45·4)]. IGF-II levels were significantly reduced in IUGR [201·4 μg/l (CI 190·2;212·6)] compared to AGA neonates [231·2 μg/l (CI 220·6;241·9)]. A trend for lower IGF-II concentrations was observed in IUGR when compared to SGA neonates [232·0 μg/l (CI 207·2;256·8)]. These differences could not be explained by confounding. For IGFBP-1, a trend towards higher values in IUGR was observed. CONCLUSIONS: Low IGF-I cord blood concentrations in hypotrophic neonates after IUGR might not only result from low birthweight per se, but also reflect prenatal placental environment. Alterations of the IGF axis could be in the causal pathway of IUGR and thus constitute a potential surrogate marker for IUGR in the assessment of foetal programming.
Authors: Paul J Rozance; Laura Zastoupil; Stephanie R Wesolowski; David A Goldstrohm; Brittany Strahan; Melanie Cree-Green; Melinda Sheffield-Moore; Giacomo Meschia; William W Hay; Randall B Wilkening; Laura D Brown Journal: J Physiol Date: 2017-10-26 Impact factor: 5.182
Authors: Ionel Sandovici; Aikaterini Georgopoulou; Vicente Pérez-García; Antonia Hufnagel; Jorge López-Tello; Brian Y H Lam; Samira N Schiefer; Chelsea Gaudreau; Fátima Santos; Katharina Hoelle; Giles S H Yeo; Keith Burling; Moritz Reiterer; Abigail L Fowden; Graham J Burton; Cristina M Branco; Amanda N Sferruzzi-Perri; Miguel Constância Journal: Dev Cell Date: 2021-12-27 Impact factor: 12.270