Literature DB >> 2611779

Lactonization of GD1b ganglioside under acidic conditions.

R Bassi1, L Riboni, S Sonnino, G Tettamanti.   

Abstract

Gangliosides that contain the disialosyl residue alpha-Neu5Ac-(2--8)-alpha-Neu5Ac-(2--3)- can lactonize in the presence of traces of acid and this reaction has been studied in detail on GD1b [beta-Gal-(1--3)-beta-GalNAc-(1 --4)-[alpha-Neu5Ac-(2--8)-alpha-Neu5Ac-(2 --3)]-beta-Gal-(1--4)-beta-Glc-1--1)-Cer]. Lactonization occurs rapidly at a proton-ganglioside molar ratio of less than 1. At equilibrium, the ratio of GD1b to its lactone is 3:7. The data suggest the possibility that a proton-driven lactonization of gangliosides may occur in vivo.

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Year:  1989        PMID： 2611779     DOI： 10.1016/0008-6215(89)85113-4

Source DB:  PubMed          Journal:  Carbohydr Res        ISSN： 0008-6215            Impact factor:   2.104


  6 in total

1.  Ganglioside analysis by thin-layer chromatography matrix-assisted laser desorption/ionization orthogonal time-of-flight mass spectrometry.

Authors:  Vera B Ivleva; Lisa M Sapp; Peter B O'Connor; Catherine E Costello
Journal:  J Am Soc Mass Spectrom       Date:  2005-09       Impact factor: 3.109

2.  Gangliosides and Cell Surface Ganglioside Metabolic Enzymes in the Nervous System.

Authors:  Massimo Aureli; Laura Mauri; Emma Veronica Carsana; Dorina Dobi; Silvia Breviario; Giulia Lunghi; Sandro Sonnino
Journal:  Adv Neurobiol       Date:  2023

3.  AP-MALDI Mass Spectrometry Imaging of Gangliosides Using 2,6-Dihydroxyacetophenone.

Authors:  Shelley N Jackson; Ludovic Muller; Aurelie Roux; Berk Oktem; Eugene Moskovets; Vladimir M Doroshenko; Amina S Woods
Journal:  J Am Soc Mass Spectrom       Date:  2018-03-16       Impact factor: 3.109

4.  Cultured cerebellar granule cells, but not astrocytes, produce an ester of ganglioside GD1b, presumably GD1b monolactone, from exogenous GD1b.

Authors:  R Bassi; L Riboni; G Tettamanti
Journal:  Biochem J       Date:  1994-09-15       Impact factor: 3.857

5.  Glycan side reaction may compromise ETD-based glycopeptide identification.

Authors:  Zsuzsanna Darula; Katalin F Medzihradszky
Journal:  J Am Soc Mass Spectrom       Date:  2014-03-25       Impact factor: 3.109

6.  Shotgun glycomics: a microarray strategy for functional glycomics.

Authors:  Xuezheng Song; Yi Lasanajak; Baoyun Xia; Jamie Heimburg-Molinaro; Jeanne M Rhea; Hong Ju; Chunmei Zhao; Ross J Molinaro; Richard D Cummings; David F Smith
Journal:  Nat Methods       Date:  2010-12-05       Impact factor: 28.547
  6 in total

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